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Mouse P10 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

ABSTRACT: Gene expression profiling of mouse cerebellum in which the experimental strain conditionally lack the Smarca5 gene that encodes for the catalytic subunit of multiple chromatin remodeling complexes. Deletion of Smarca5 was restricted to those cells expressing Cre-recombinase driven by the Nestin promoter.

ORGANISM(S): Mus musculus

PROVIDER: GSE42370 | GEO | 2014/04/30

SECONDARY ACCESSION(S): PRJNA181201

REPOSITORIES: GEO

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Mouse P10 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

Project description:Gene expression profiling of mouse cerebellum in which the experimental strain conditionally lack the Smarca5 gene that encodes for the catalytic subunit of multiple chromatin remodeling complexes. Deletion of Smarca5 was restricted to those cells expressing Cre-recombinase driven by the Nestin promoter. Comparison of gene expression in P10 cerebella of Smarca5 cKO mice versus wild type controls. Three samples of each strain were used in a total of 3 replicates.

2014-04-30 | E-GEOD-42370 | biostudies-arrayexpress

Mouse P0 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

2014-04-30 | GSE42369 | GEO

Mouse P0 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

Project description:Gene expression profiling of mouse cerebellum in which the experimental strain conditionally lack the Smarca5 gene that encodes for the catalytic subunit of multiple chromatin remodeling complexes. Deletion of Smarca5 was restricted to those cells expressing Cre-recombinase driven by the Nestin promoter. Comparison of gene expression in P0 cerebella of Smarca5 cKO mice versus wild type controls. Three samples of each strain were used in a total of 4 replicates.

2014-04-30 | E-GEOD-42369 | biostudies-arrayexpress

Mouse cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-04-30 | E-GEOD-42371 | biostudies-arrayexpress

Mouse cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-04-30 | GSE42371 | GEO

ISWI ATP-ases, Smarca5 and Smarca1, are required for normal murine neocortical development

Project description:Chromatin remodeling complexes modulate DNA accessibility permitting neuronal progenitor cells to proliferate and differentiate to form the mammalian neocortex. Smarca5 and Smarca1 are the ISWI ATP-ase proteins, within a variety of chromatin remodelling complexes. We created a mouse model with a truncated Smarca1, which inactivates the ATPase nucleosome rearranging activity of the protein. Secondly, using the cre/loxp system, we conditionally removed exon 5 of the Smarca5 gene, resulting in a null allele solely in the cortex of the mouse. Ultimately, we knockout (KO) both the Smarca5 and Smarca1 genes to analyze neocortical neurogenesis at E13.5 and identify their cooperative role during embryonic brain development. The DKO mice reveal significant forebrain hypoplasia.

2023-04-12 | GSE172294 | GEO

RNA Sequencing of postnatal mouse Math1-Cre; Sufu flox/- cerebellum

Project description:Transcriptional profiling to identify genes differentially regulated by Sufu during cerebellum development. Sufu was specifically deleted from the granule neuron compartment using Math1-driven Cre recombinase.

2020-01-15 | GSE143671 | GEO

Conditional knockout of p300 and Cbp in mouse rod photoreceptors

Project description:Ep300 and/or CrebBP were conditionally knocked out in differentiating mouse rod photoreceptors using opsin-driven Cre recombinase to elucidate the role of these transcription coactivators in photoreceptor gene expression regulation.

2013-07-29 | GSE47699 | GEO

Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [ATAC-seq]

Project description:Genetic models suggested that SMARCA5 was required for DNA templated events including transcription, DNA replication and DNA repair. We engineered a degron tag into the endogenous alleles of SMARCA5, a catalytic component of the imitation switch (ISWI) complexes, in three different human cell lines to define the effects of rapid degradation of this key regulator. Degradation of SMARCA5 was associated with a rapid increase in global nucleosome repeat length, which may allow greater chromatin compaction. However, there were few changes in nascent transcription within the first 6hr of degradation. Nevertheless, we demonstrated a requirement for SMARCA5 to control nucleosome repeat length at G1/S and during the S phase. SMARCA5 co-localized with CTCF and H2A.Z, and we found a rapid loss of CTCF DNA binding and disruption of nucleosomal phasing around CTCF binding sites. This spatiotemporal analysis indicates that SMARCA5 is continuously required for maintaining nucleosomal spacing.

2023-03-01 | GSE160469 | GEO

Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [CUT&RUN]

2023-03-01 | GSE160468 | GEO

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