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Mesothelioma differential expression

ABSTRACT: To investigate the molecular events controlling malignant transformation of human pleural cells, we compared constitutive gene expression of mesothelioma cells to that of pleural cells. Using cDNA microarray and high-density filter array, we assessed expression levels of > 6500 genes. Most of the highly expressed transcripts were common to both cell lines and included genes associated with stress response and DNA repair, outcomes consistent with the radio- and chemo-resistance of mesothelioma. Interestingly, of the fewer than 300 genes that differed between cell lines, most functioned in (i) macromolecule stability, (ii) cell adhesion and recognition, (iii) cell migration (invasiveness), and (iv) extended cell division Keywords: c-DNA array from Incyte Pharmaceuticals™, cell line comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE4241 | GEO | 2006/02/16

SECONDARY ACCESSION(S): PRJNA94899

REPOSITORIES: GEO

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