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Genome wide profiling of FOXE1 binding sites in PCCL3 rat cells

ABSTRACT: FoxE1 transcriptional profiling of rat PCCL3 cells comparing wild type cells with FoxE1 silenced cells and scramble treated with FoxE1 silenced cells.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE42497 | GEO | 2013/05/14

SECONDARY ACCESSION(S): PRJNA182148

REPOSITORIES: GEO

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Genome wide profiling of FOXE1 binding sites in PCCL3 rat cells

Project description:FoxE1 transcriptional profiling of rat PCCL3 cells comparing wild type cells with FoxE1 silenced cells and scramble treated with FoxE1 silenced cells. Three-condition experiment, FoxE1 silenced vs. Wild type cells. Biological replicates: 4 replicates, 1pooled sample dye-swap. and FoxE1 silenced vs scramble treated cells. Biological replicates: 4 replicates, 1 pooled sample dye-swap.

2013-05-14 | E-GEOD-42497 | biostudies-arrayexpress

PAX8 transcriptional profiling in rat PCCL3 cells

Project description:PAX8 transcriptional profiling of rat PCCL3 cells comparing wild type cells with PAX8 silenced cells and scramble treated with PAX8 silenced cells

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Genome wide profiling of PAX8 binding stes in PCCL3 rat cells

2012-06-28 | GSE26871 | GEO

Genome wide profiling of PAX8 binding stes in PCCL3 rat cells

Project description:Analysis of PAX8 binding sites by chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq) in PCCL3 rat cells. Results provide insight into the contribution of this regulatory factor to transcription genome-wide. We generate a genome wide map of PAX8 binding sites in PCCL3 cells using as negative control an input DNA obtained just prior to Pax8 immunoprecipitation

2012-06-27 | E-GEOD-26871 | biostudies-arrayexpress

Glis3 regulates the expression of thyroid hormone synthetic genes in coordination with other thyroid transcription factors

Project description:Comparison of cistromes from PAX8, NKX2.1, and FOXE1 ChIP-Seq analysis using mouse thyroid gland and rat thyrocyte PCCl3 cells revealed that there is a significant overlap between GLIS3 binding regions and those of PAX8, NKX2.1, and FOXE1 in genes associated with thyroid hormone biosynthesis.

2023-04-06 | GSE207777 | GEO

Differential gene expression analysis of iodide treated rat thyroid follicular cell line PCCl3

Project description:The inhibitory effect of supra physiological iodide concentrations on thyroid hormone synthesis (Wolff-Chaikoff effect) and thyrocyte proliferation is largely know as iodine autoregulation. However, the molecular mechanisms by which iodide excess modulate thyroid functions remains unclear. In this work, we analyzed the rat follicular cell PCCl3 transcriptome profile under untreated and treated conditions with 10-3M sodium iodide (Na/I). Serial Analysis of Gene Expression revealed several transcripts differentially expressed in response to the iodide showing that excess iodide affects almost all aspects of thyroid cell function and differentiation acting on the iodine autoregulatory mechanism through a complex process. Keywords: comparative genomic analysis PCCl3 cells were cultured under untreated and treated conditions with 10-3M NaI during 24 hours

2007-11-01 | E-GEOD-7174 | biostudies-arrayexpress

RNA-seq of immortalized rat thyrocytes (PCCl3) treated with two thyroid disrupting chemicals (ethylenethiourea and chlorpyrifos) against untreated controls

Project description:The transcriptomic dose-dependent response of rat immortalized thyrocytes to two thyroid disrupting chemicals was investigated by RNA-seq experiment. PCCl3 cells were exposed for one week to different doses of ethylenethiourea (ETU) and chlorpyrifos (CPF) and to their combinations.

2016-12-06 | E-MTAB-5269 | biostudies-arrayexpress

Rattus norvegicus

Project description:Genome wide profiling of FOXE1 binding sites in PCCL3 rat cells

| PRJNA182148 | ENA

Differential gene expression analysis of iodide treated rat thyroid follicular cell line PCCl3

2007-11-02 | GSE7174 | GEO

MEF2D binding sites in rat hippocampal neurons

Project description:We analyzed the binding profiles of MEF2D, a member of MEF2 family transcription factors, in rat hippocampal neurons. Keywords: ChIP-chip

2009-01-15 | GSE13551 | GEO

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