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Methylation profile of dermal MSCs derived from psoriasis patients and normal control

ABSTRACT: Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear.We have found that the gene expression profile of psoriatic dermal MSCs was distinct different from normal MSCs. We proposed to investigate the DNA methylation profile of psoriatic MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42634 | GEO | 2012/11/30

SECONDARY ACCESSION(S): PRJNA182385

REPOSITORIES: GEO

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methylation profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear.We have found that the gene expression profile of psoriatic dermal MSCs was distinct different from normal MSCs. We proposed to investigate the DNA methylation profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the DNA methylation profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42634 | biostudies-arrayexpress

microRNA expression profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear. We proposed to investigate the microRNA expression profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the microRNA expression profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42633 | biostudies-arrayexpress

mRNA expression profile of dermal MSCs derived from psoriasis patients and normal control

Project description:Several studies have suggested that MSCs have pleiotropic immuno-modulatory effects, including inhibition of T cell proliferation, suppression of NK cells proliferation, modulation of cytokine production, and inhibition of dendritic cell (DC) maturation etc. But the exactly mechanism are still largely unclear. We proposed to investigate the mRNA expression profile of psoriatic MSCs. 6 patients and 6 normal control were inrolled in the study, the mRNA expression profile of dermal MSCs were studied using the microarry.

2012-11-30 | E-GEOD-42632 | biostudies-arrayexpress

mRNA expression profile of dermal MSCs derived from psoriasis patients and normal control

2012-11-30 | GSE42632 | GEO

microRNA expression profile of dermal MSCs derived from psoriasis patients and normal control

2012-11-30 | GSE42633 | GEO

Tsirvouli2023 - PsoriaSys model: a multiscale psoriasis model

Project description:The PsoriaSys model represent molecular and cellular interactions in the psoriatic microenvironment. The model is able to simulate the dynamics of keratinocyte proliferation in response to psoriatic triggers and perturbations. Dynamic simulations coupled with network graph metrics were used to identify target pairs with high influence on the system's behavior. Two target pairs, namely the combinatorial inhibition of neutrophil activation with PGE2 production or STAT3 activation, were predicted to reduce keratinocyte hyperproliferation at similar levels as IL-17 inhibition, which is the current standard treatment for moderate-to-severe cases.

2024-02-06 | MODEL2308300001 | BioModels

Differentially expressed (DE) genes analysis in synovial fluid mesenchymal stem cells (SF-MSCs), SF-MSC derived iPSCs and iPSC derived MSCs (iPSC-MSCs)

Project description:We report the application of next-generation sequencing (NGS) to analysis the gene expression profile among three different cells:SF-MSCs, iPSCs and iPSC-MSCs. Our results shown that iPSC-MSCs were more similar to SF-MSCs than iPSCs.

2018-10-04 | GSE120800 | GEO

Gene expression profile of modified MSCs

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single cell multiome for MSCs

Project description:we used single-cell multiome analysis to profile the transcriptome and epigenome of MSCs from four healthy donors.

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Monocytes as endogenous immunologic biosensors: identification of inflammatory, adhesion, and mTOR-related signatures in psoriasis

Project description:Psoriatic monocyte singlets and doublets (MonD) have a distinct gene expression profile compared to singlet control monocytes. Furthermore, there is dysregulation of adhesion markers, tetraspanins, adipocytokines, and mTOR-related genes in singlets and doublets from both psoriatic and control individuals.

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