Direct reprogramming of human fibroblasts to functional hepatocyte-like cells

ABSTRACT: Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic marker genes, and acquiring many mature hepatocyte functions in vitro and in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42643 | GEO | 2014/03/06

SECONDARY ACCESSION(S): PRJNA182503

REPOSITORIES: GEO