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BL2 cells stimulated with B cell specific paracrine stimuli

ABSTRACT: Expression data of BL2 Burkitt Lymphoma cell line (controls and samples treated with different B cell specific stimuli)

ORGANISM(S): Homo sapiens

PROVIDER: GSE42660 | GEO | 2013/02/01

SECONDARY ACCESSION(S): PRJNA182718

REPOSITORIES: GEO

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BL2 cells stimulated with B cell specific paracrine stimuli

Project description:Expression data of BL2 Burkitt Lymphoma cell line (controls and samples treated with different B cell specific stimuli) BL2 cells were cultured in RPMI and stimulated with the respective agents (rhCD40L, rhIL21, rhBAFF, LPS and antiIgM F(ab) fragments) for indicated timepoints. Cells were harvested and total RNA was isolated for gene expression profiling. The experiments were conducted in 2-3 biological replicates.

2013-02-01 | E-GEOD-42660 | biostudies-arrayexpress

Gene expression profile for BL2 and BL2 AID-/- cell lines

Project description:AID (activation-induced cytidine deaminase) is expressed at low levels in many tissue types but is most highly expressed in germinal center B cells where it deaminates cytidine to uracil during somatic hypermutation and class switch recombination of the immunoglobulin genes. In addition to this critical role in immune diversification, aberrant targeting of AID contributes to oncogenic point mutations and chromosome translocations associated with B cell malignancies. Thus, to explore a role for AID in DNA demethylation in B cell lymphoma, we performed genome-wide gene expression profiling in BL2 and AID-deficient (AID-/-) BL2 cell lines (Burkitt lymphoma that can be induced to express high levels of AID).

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DNA methylation profile for BL2 and BL2 AID-/- cell lines

Project description:AID (activation-induced cytidine deaminase) is expressed at low levels in many tissue types but is most highly expressed in germinal center B cells where it deaminates cytidine to uracil during somatic hypermutation and class switch recombination of the immunoglobulin genes. In addition to this critical role in immune diversification, aberrant targeting of AID contributes to oncogenic point mutations and chromosome translocations associated with B cell malignancies. Thus, to explore a role for AID in DNA demethylation in B cell lymphoma, we performed genome-wide methylation profiling in BL2 and AID-deficient (AID-/-) BL2 cell lines (Burkitt lymphoma that can be induced to express high levels of AID).

2016-11-01 | GSE81215 | GEO

B-cell activating factor (BAFF) stimulation of Burkitt Lymphoma cell line [Affymetrix]

Project description:Microarray profiling of Burkitt Lymphoma cell line (BL2) with B-cell activating factor (BAFF) for 24 hrs . The Burkitt Lymphoma cell line were either only cultured in cell culture medium supplemented with 10 mM HEPES at 1 × 106 cells/ml or additionally incubated with B-cell activating factor (BAFF) for 24 hrs

2018-05-23 | GSE100111 | GEO

B-cell activating factor (BAFF) stimulation of Burkitt Lymphoma cell line [RNA-Seq]

Project description:RNA-Seq profiling of Burkitt Lymphoma cell line (BL2) with B-cell activating factor (BAFF) for 24 hrs . The Burkitt Lymphoma cell line were either only cultured in cell culture medium supplemented with 10 mM HEPES at 1 × 106 cells/ml or additionally incubated with B-cell activating factor (BAFF) for 24 hrs

2018-05-23 | GSE99768 | GEO

Burkitt lymphoma cells vs. Lymphoblastoid B cells

Project description:To identify genes mediating tumor transformation we compared the transcriptome of five Burkitt lymphoma (BL) cell lines (tumor cells) with that of a pool of three lymphoblastoid B-cell lines (LCL; immortal, but not tumor cells). Each BL cell line was considered as a biological replicate. BL cell lines: DG-75, Ramos, BL2, Mutu-I and Akata. LCL cell lines: X50-7, IB4 and Dana.

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Brevibacterium aurantiacum strain:BL2

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Expression data from Burkitt's Lymphoma cell line BL2 transiently transfected with Epstein-Barr Virus miRNA mimics BART 18-5p, 10, 14*

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