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TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase

ABSTRACT: To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42922 | GEO | 2013/02/11

SECONDARY ACCESSION(S): PRJNA183876

REPOSITORIES: GEO

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TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase

Project description:To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h. Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose NY-ESO-1 multimer

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Zfp36l1 establishes the high affinity CD8 T cell response by directly linking TCR affinity to cytokine sensing

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