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Comparative gene-expression analysis on the first-generation offspring of irradiated male and female mice

ABSTRACT: Invstigation of whole genome gene expression level changes in kidney of the male offspring of BALB/c male and female mice exposed to 1 Gy of acute X-rays The design of this study is further described in Abouzeid Ali, H. E., R. C. Barber, and Y. E. Dubrova. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732(1): 21-25. (PMID: 22289278).

ORGANISM(S): Mus musculus

PROVIDER: GSE42933 | GEO | 2013/01/29

SECONDARY ACCESSION(S): PRJNA183954

REPOSITORIES: GEO

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Comparative gene-expression analysis on the first-generation offspring of irradiated male and female mice

Project description:Invstigation of whole genome gene expression level changes in kidney of the male offspring of BALB/c male and female mice exposed to 1 Gy of acute X-rays The design of this study is further described in Abouzeid Ali, H. E., R. C. Barber, and Y. E. Dubrova. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732(1): 21-25. (PMID: 22289278). A six 12x135K chip study using total RNA extracted from kidney of control and treated BALB/c male mice. The expression of 42,575 genes was measured with at least two-fold technical redundancy.

2013-01-29 | E-GEOD-42933 | biostudies-arrayexpress

Expression analysis of the first-generation offspring of irradiated male mice

Project description:Investigation of whole genome gene expression level changes in kidney, brain, liver and spleen of the offspring of CBA/Ca and BALB/c male mice exposed to 1 Gy of acute X-rays The pattern of gene expression of a number of circadian rhythm genes in the offspring of irradiated males is compromised A twenty-two 12x135K chip study using total RNA extracted from kidney, brain, liver and spleen of control CBA/Ca and BALB/c male mice and the first-generation offspring of male mice exposed to 1 Gy of acute X-rays. The expression of 42,575 genes was measured with two-fold technical redundancy.

2012-12-17 | E-GEOD-42621 | biostudies-arrayexpress

Expression analysis of the first-generation offspring of irradiated male mice

2012-12-17 | GSE42621 | GEO

Transcriptomic responses in mouse blood during the first week after in vivo gamma irradiation

Project description:Due to limitations of available human models for development of gene expression based radiation biodosimetry, many such studies have made use of mouse models. To provide a broad view of the gene expression response to irradiation in the mouse, we have exposed male C57BL/6 mice to 0, 1.5, 3, 6 or 10 Gy of gamma rays, sacrificing groups of the mice at 1, 2, 3, 5, or 7 days after exposure. Global gene expression was then profiled in blood from individual mice using Agilent microarrays. In general, we found increasing numbers of genes differentially expressed with increasing dose, with more prolonged responses after the higher doses.

2019-11-19 | GSE124612 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 2)

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and mated with control females. Tissue samples were taken from eigth-week old male offspring of control and treated males. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

2014-05-29 | GSE57522 | GEO

RNA-seq of irradiated intestinal organoid-derived subcutaneous heterotopic tumours and non-irradiated controls

Project description:In this project, we aimed to examine the transcriptional changes that occur after irradiation of intestinal organoid-derived subcutaneous heterotopic tumors over a 7 day period post-radiation treatment. AKPT (villinCreER;Apcfl/fl;KrasG12D/+;Trp53fl/fl;TgfbrIfl/fl) intestinal organoids were cultured, then suspended in a 50:50 phosphate buffered-saline and Matrigel mixture and subcutaneously implanted into male C57BL/6 mice. Two weeks after implantation, mice were given either a single dose of 15 Gy radiation or 3 doses of 7 Gy radiation. Tumours were harvested 4 hours, 24 hours, 3 days, and 7 days after receiving the single dose of 15 Gy or the final dose of 7 Gy radiation, as well as from corresponding non-irradiated controls. RNA was extracted from the collected tumours and processed for RNA sequencing.

2023-01-25 | E-MTAB-12538 | biostudies-arrayexpress

Expression analysis of the effects of methyl-donor deficient diet on male mice

Project description:BALB/c male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0, 2 and 6 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver and kidney of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

2012-12-13 | GSE42744 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 3)

Project description:CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed 0 and 2 weeks after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in liver of mice sacrificed immediatelly after the end of dietary restrictions is significatly altered.

2014-05-29 | GSE57523 | GEO

Expression analysis of the effects of methyl-donor deficient diet on male mice (part 1)

Project description:BALB/c and CBA/Ca male mice were maintained for 8 weeks on a synthetic diet lacking in choline and folic acid and sacrificed after the end of dietary restrictions. The design of this study is further described in Voutounou, M., C .D. Glen, and Y. E. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734(1):1-4 (PMID: 22569175) The pattern of gene expression in spleen of mice sacrificed immediatelly after the end of dietary restrictions is not significatly altered.

2014-05-29 | GSE57521 | GEO

Analysis of mRNA expression between irradiated and non-irradiated keloid-derived primary cells.

Project description:This study aims to compare mRNA expression between irradiated and non-irradiated keloid-derived primary cells by RNA-Seq. In this study, keloid-derived primary cells that were isolated from patients, and then divided into three groups and each group had four repeats. The first group of cells was treated without radiation, the second group of cells were received 4 Gy delivered in 2-Gy fractions once per day over 2 days and the third group of cells were received 8 Gy delivered in 2-Gy fractions once per day over 4 days.The last two groups of cells were irradiated at a fixed rate of 1.15 Gy/min using an X-ray linear accelerator (Rad Source Technologies Inc., Suwanee, GA, USA). 24 hours post irradiation of the third group of cells, all keloid-derived primary cells were collected and subjected to mRNA expression analysis.

2020-07-11 | GSE154234 | GEO

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