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Protein Determinants of Meiotic DNA Break Hotspots

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Schizosaccharomyces pombe

PROVIDER: GSE43122 | GEO | 2012/12/26

SECONDARY ACCESSION(S): PRJNA184594

REPOSITORIES: GEO

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Functional organization of protein determinants of meiotic DNA break hotspots.

Project description: Not available

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Protein Determinants of Meiotic DNA Break Hotspots (dataset 2)

Project description:Meiotic recombination, crucial for proper chromosome segregation and genome evolution, is initiated by programmed DNA double-strand breaks (DSBs) in budding and fission yeasts and likely all sexually reproducing species. In fission yeast, DSBs occur up to several hundred times more frequently at special sites, called hotspots, than in other regions of the genome. What distinguishes hotspots from cold regions is a major unsolved problem, although transcription factors determine some hotspots. We report here the discovery that three coiled-coil proteins -- Rec25, Rec27, and Mug20 -- bind essentially all hotspots with unprecedented, high specificity even without DSB formation. These small proteins are components of linear elements, are related to synaptonemal complex proteins, and are essential for nearly all DSBs at most hotspots. Our results indicate that these hotspot determinants activate or stabilize the DSB-forming protein Rec12 (Spo11 homolog) rather than promote its binding to hotspots. We propose here a new paradigm for hotspot determination and crossover control by linear element proteins.

2012-12-26 | GSE43121 | GEO

Protein Determinants of Meiotic DNA Break Hotspots (dataset 1)

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Genomic features shaping the landscape of meiotic double-strand break hotspots in maize

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-07-14 | GSE84369 | GEO