Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis

ABSTRACT: To explore the epigenetic contribution to retinal development, we generated conditional knockout alleles of DNA methytransferase-1 (Dnmt1) mediated by Rx-Cre in mice. The results demonstrate a unique function of DNMT1-mediated DNA methylation in controlling RPE apicobasal polarity and neural retina differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE43951 | GEO | 2013/01/31

SECONDARY ACCESSION(S): PRJNA188220

REPOSITORIES: GEO