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Cardiac gene expression profiling of neonatal Salvador mutant mice

ABSTRACT: In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cre activity. Total RNA from P8-stage hearts were used for expression profiling.

ORGANISM(S): Mus musculus

PROVIDER: GSE44103 | GEO | 2015/05/12

SECONDARY ACCESSION(S): PRJNA188669

REPOSITORIES: GEO

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Cardiac gene expression profiling of neonatal Salvador mutant mice

Project description:In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cre activity. Total RNA from P8-stage hearts were used for expression profiling. Genes transcriptionally regulated by the Hippo pathway during cardiogenesis were identifed through expression profiling in Salvador mutant (Salv CKO) neontate hearts. Total RNA from postnatal day 8 (P8)-stage hearts was purified to generate biological replicate samples (2 control and 2 Salv CKO) and generate expression profiles. 3 technical replicates were used for each sample.

2015-05-12 | E-GEOD-44103 | biostudies-arrayexpress

Cardiac gene expression profiling of Salvador mutant mice

2011-02-12 | GSE27259 | GEO

Cardiac gene expression profiling of Salvador mutant mice

Project description:In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cre activity. Total RNA from embryonic hearts were used for expression profiling of 17,455 unique genes. Genes transcriptionally regulated by the Hippo pathway during cardiogenesis were identifed through expression profiling of 17,455 unique genes in Salvador mutant (Salv CKO) embryonic hearts. Total RNA from E9.5-stage hearts were pooled into biological replicate samples (2 control and 2 Salv CKO) and were used to generate expression profiles.

2011-02-12 | E-GEOD-27259 | biostudies-arrayexpress

Cardiac profiling of Yap-bound chromatin in neonatal Salvador mutant mice

Project description:In this study, we identified chromatin regions bound by YAP, a major effector of the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and and tamoxifen inducible Myh6-cre/Esr1 allele, Cre activity was induced with 4 consecutive intraperitoneal (i.p.) or subcutaneous injections of tamoxifen from P7-P10.

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Dicer conditional knockout embryonic heart mutant vs control array

Project description:The goal is to find out the gene expression changes when Dicer was inactivated in the murine heart. Keywords: Dicer mutant Dicer gene was specifically inactivated in the mouse heart using cardiac specific Nkx2.5 Cre knock-in line. Embryonic day 11.5 heart from mutant and control hearts were compared in triplicates.

2010-06-11 | E-GEOD-7343 | biostudies-arrayexpress

Lats1/2 depletion in male sertoli cells

Project description:In order to understand the role of Hippo pathway in mice testes, we inactivated lats1/2 in a transgenic mouse model using the cre recombinase system in Sertoli cells. RNAseq analysis on whole e15.5 testes were performed on male mice

2024-04-22 | GSE243216 | GEO

miR-302-367 regulates cardiomycyte proliferation and differentiation during development

Project description:To define the role of miR-302-367 cluster in cardiac development, we overexpressed miR-302-367 cluster in mouse heart by using R26R-miR-302-367; Nkx2.5-Cre mice. This data set contains the microarrays examining gene expression in the hearts of R26R-miR-302-367; Nkx2.5-Cre mice at postnatal day 14. We overexpressed miR-302-367 cluster in developing mouse heart using Nkx2.5-Cre mouse line

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miR-302-367 regulates cardiomycyte proliferation and differentiation during development

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mTor Neonatal Heart Regeneration

Project description:Global proteomics data captured from P8 hearts, 7 days post-MI or sham surgery. Hearts were treated at 4, 5, and 6 days post surgery with saline or rapamycin.

2023-07-13 | MSV000092436 | MassIVE

Cyldko

Project description:Effect of Cyld inactivation in liver. The Cyld gene was conditionally inactivated specifically in the liver by crossing mice carrying floxed exon 9 allele of Cyld with Alfp-Cre transgenic mice. Liver RNAs from Cyld lox/lox-AlfpCre mice were compared with RNAs prepared from the livers of wild type littermates.

2012-02-01 | E-MEXP-3478 | biostudies-arrayexpress

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