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The Neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

ABSTRACT: We performed an RNA Sequencing experiment on dorsal hippocampal tissue from four groups of animals: Baf53b+/- homecage (Baf53b+/- HC); Baf53b+/- behavior (Baf53b+/- Beh); wildtype homecage (WT HC); and wildtype behavior (WT Beh). Homecage animals were sacrificed directly from the animal's cage. Behavior animals were sacrificed thirty minutes following Object Location Memory training. The objective of this study was to examine activity regulated gene expression following a learning event (HC vs Beh) in wildtype and Baf53b+/- mutant mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE44229 | GEO | 2013/03/24

SECONDARY ACCESSION(S): PRJNA189208

REPOSITORIES: GEO

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The Neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.

Project description:We performed an RNA Sequencing experiment on dorsal hippocampal tissue from four groups of animals: Baf53b+/- homecage (Baf53b+/- HC); Baf53b+/- behavior (Baf53b+/- Beh); wildtype homecage (WT HC); and wildtype behavior (WT Beh). Homecage animals were sacrificed directly from the animal's cage. Behavior animals were sacrificed thirty minutes following Object Location Memory training. The objective of this study was to examine activity regulated gene expression following a learning event (HC vs Beh) in wildtype and Baf53b+/- mutant mice. Examination of gene expression following a learning event in wildtype and Baf53b+/- mutant mice in dorsal hippocampus.

2013-03-24 | E-GEOD-44229 | biostudies-arrayexpress

HDAC3-mediated regulation of the circadian gene Per1 contributes to age-related impairments in hippocampal memory and synaptic plasticity

Project description:We performed an RNA Sequencing experiment on dorsal hippocampal tissue from six groups of animals: Aging (18-20-month-old) HDAC3flox/flox homecage (H3F-HC); Aging (18-20-month-old) HDAC3flox/flox 60min post training (H3F-BV); Aging (18-20-month-old) wildtype homecage (OWT-HC); Aging (18-20-month-old) wildtype 60min post training (OWT-BV); Young (2-4-month-old) wildtype homecage (YWT-HC); Young (2-4-month-old) wildtype 60min post training (YWT-BV). Homecage animals were sacrificed directly from the animal's cage. Behavior animals were sacrificed sixty minutes following a 10min Object Location Memory training session.

2018-07-16 | GSE94832 | GEO

Salmonella enterica subsp. Enteric sv. Typhimurium in vivo induced enterocyte transcriptional response

Project description:1-day-old C57BL/6 mice were left untreated (co) or orally infected with 10E2 CFU wildtype (wt) or delta invC SPI1 mutant Salmonella Typhimurium (ATCC14028). Four biological replicates obtained from individual animals were exmained; each group contained animals from at least 2 different litters. On day 4 p.i., animals were sacrificed and intestinal epithelial cells were isolated from total small intestine (protocol according to: Lotz et al., J. Exp. Med. 2006). Total RNA was isolated by TriZol and its purity was examined using a Bioanalyzer. We used microarrays to detail the global gene expression in primary total isolated intestinal epithelial cells.

2014-09-01 | GSE51160 | GEO

Gene expression in the mouse brain during spontaneous sleep and prolonged wakefulness

Project description:These studies address temporal changes in gene expression during spontaneous sleep and extended wakefulness in the mouse cerebral cortex, a neuronal target for processes that control sleep; and the hypothalamus, an important site of sleep regulatory processes. We determined these changes by comparing expression in sleeping animals sacrificed at different times during the lights on period, to that in animals sleep deprived and sacrificed at the same diurnal time. Keywords: gene expression, temporal changes, brain, behavior, sleep,

2007-02-11 | GSE6514 | GEO

Mir-132/212 shapes age-dependent transcriptome and is required for binocular matching of orientation preference and depth perception.

Project description:We performed RNA sequencing and smallRNA sequencing experiments on visual cortex tissues from three groups of animals: wildtype mice postnatal day 10 (P10-WT), wildtype mice postnatal day 28 (P28-WT), and miR-132/212 null mice postnatal day 28 (P28-KO).

2017-03-03 | GSE95649 | GEO

spatial transcriptome

Project description:CA1-specific brain tissue from the hippocampal formation was isolated at baseline (homecage condition) in wildtype and NEIL1, NEIL2 or NEIL1&2-deficient mice. NEILs are DNA glycosylases potentially involved in transcription regulation. RNA was extracted and sequenced.

2021-04-30 | GSE160621 | GEO

Transcription profiling by array of mouse liver after isoproterenol treatment

Project description:Mice were acclimatized for 2 weeks and randomly assigned to treatment and control groups (five per group). Animals were given a single dose of 250, 50, 5 and 0.5 mg/kg isoproterenol by oral gavage alongside 0.9% saline (vehicle control group)and sacrificed after eight hours. Total mouse liver RNA was isolated and used for the microarry analysis on custom oligonucleotide DNA microarray, the HC ToxArray V1.2.<br><br>

2010-08-01 | E-MEXP-2716 | biostudies-arrayexpress

Project description:Wildtype mice at either 3 or 12 months old were subjected to intrahippocampal injection with sarkosyl insoluble brain extracts from either human control or Alzheimer's disease brain. Mice were incubated for 1, 3 or 5 months and then sacrificed. The hippocampus from one hemisphere was used to extract total RNA that was then subjected to polyA-selection and whole transcriptome sequencing. 3 and 12 month old animals were processed in seperate batches and comparisons between control and Alzheimer's disease injected animals from each timepoint were conducted

2021-08-31 | GSE169686 | GEO

Expression profile of the fat body from bigmax mutant and wildtype third instar Drosophila melanogaster larvae

Project description:To identify genes differentially expressed in the fatbody of Drosphila melanogaster bigmax mutants, a loss-of-function allele was generated by P-element mobilization. Mutant and wildtype first instar larvae were raised on two different sources of food, control and high-sugar media. When the animals reached the wandering third instar stage, animals were sacrificed and their fat bodies dissected. Total RNA was extracted, labeled fluorescently and hybridized competitively to Agilent's 4x44K Drosophila Gene Expression Microarrays. On each array, three different samples were analyzed: 1. wildtype animals raised on control food, 2. wildtype animals raised on high-sugar food and 3. bigmax mutant animals raised on high-sugar food.

2013-02-27 | E-MTAB-699 | biostudies-arrayexpress

Salmonella enterica subsp. Enteric sv. Typhimurium in vivo induced enterocyte transcriptional response

2014-09-01 | E-GEOD-51160 | biostudies-arrayexpress

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