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Comparison of B-MSCs from young and old mice

ABSTRACT: Total RNA of B-MSCs from young and old mice were compared using Agilent microarrays.

ORGANISM(S): Mus musculus

PROVIDER: GSE44403 | GEO | 2014/02/18

SECONDARY ACCESSION(S): PRJNA189775

REPOSITORIES: GEO

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Comparison of B-MSCs from young and old mice

Project description:Total RNA of B-MSCs from young and old mice were compared using Agilent microarrays. Bone marrow cells from old and young mice were labeled and sorted.

2014-02-18 | E-GEOD-44403 | biostudies-arrayexpress

Comparison of microglia of old vs. young ischemic male mice

Project description:We subjected old (21-22 month) and young (3-4 month) male C57BL/6 mice to 45 min transient oclusion of the middle cerebral artery and obtained the brain four days later. We obtained bodipy+ microglia from the ischemic brain tissue by FACS.

2022-11-29 | GSE209732 | GEO

Myelin proteome differences in old and young mice

Project description:Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is a central component in maintaining physiological peripheral nerve function, and differences in myelin maintenance, degradation, formation and clearance have been suggested to contribute to age-related PNS changes. In addition, recent proteomic studies have elucidated the complex composition of the total myelin proteome in health and its changes in neuropathy models. However, changes in the myelin proteome of peripheral nerves during ageing have not been investigated. Hence, the aim of this proteomics experiment was to define proteome changes in isolated myelin fractions during ageing, by investigating myelin proteome profiles from young (nerves from 2-3 month old mice) and old (nerves from 18 months old mice) nerves.

2023-10-19 | PXD040719 | Pride

Expression data from whole lateral ventricle choroid plexus tissue of young (two months old) and aged (eighteen months old) CD1 male mice.

Project description:We used microarrays to reveal the global expression profiles of young and old whole lateral ventricle choroid plexus tissue.

2016-07-20 | GSE82308 | GEO

MicroRNA data in the hearts from young (8 week-old) and middle-aged (15 month-old) male mice

Project description:MicroRNAs have been reported to be involved in the regulation of cellular and organismal aging. However, little is known about the role of microRNAs in cardiac aging. We used microarrays to examine microRNA profiles in the hearts from young (8 week-old) and middle-aged (15 month-old) male mice.

2019-06-14 | GSE83329 | GEO

TMT isobaric profiling of young versus old haematopoietic stem cells

Project description:Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spectra were used for peptide identification and quantitation based on TMT reporter ions. TMT isobaric comparison of old versus young haematopoietic stem and progenitor cells. Young 1 and Young 2 are samples 126 and 128 of dataset UTH_1. Old 1 and Old 2 are samples 129 and 130 of UTH_1. Young 3 is sample 131 and Old 3 is sample 130 of dataset UTH_4.

2023-10-16 | MSV000093126 | MassIVE

mRNA expression of young, mid-old, and old fibroblasts

Project description:Examination of the difference in mRNA expression profile between young, mid-old, and old fibroblasts

2023-05-19 | GSE232427 | GEO

Expression data of peripheral CD4+ T cells from young(6-8-week-old) and old(11-month-old) mice

Project description:We conducted gene expression profile analysis by using peripheral CD4+ T cells from young and old mice.Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed the most prominent biological processes altered in peripheral CD4+ T cells from young and old mice were associated with cytoplasmic DNA-sensing, AKT signaling and autoimmune disease.

2023-06-01 | GSE153462 | GEO

RNAseq of whole ovarian follicles from young and old mice.

Project description:Compare gene expression in whole ovarian follicles from young (6-12 weeks) and old (14-17 months) mice. Whole follicles,consist of the oocyte and granulosa cells. As oocytes are very difficult to extract intact from old follicles due to fibrosis, whole follicles were sequenced instead, so that old and young could be properly compared. 2-3 follicles each were sequenced from 4 old mice and 5 young mice. Each sample has both single- and paired-end runs.

2018-05-22 | E-MTAB-5952 | biostudies-arrayexpress

Bleomycin model of fibrosis and resolution phase in old and young mice

Project description:Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Young (3 months) and old (21 months) mice were treated with Bleomycin or with control saline solution and analyzed transcript and protein expression over 8 weeks (Day 0, 14, 21, 28, 35, 42, 49, 56).

2023-08-09 | PXD041050 | Pride

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