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MiRNA profiling in lung epithelial cells during infection with influenza A virus of H5N1 strain

ABSTRACT: This study aims at elucidating how H5N1 influenza infection perturbs the host's miRNA regulatory pathways that may lead to adverse pathological events, such as cytokine storm, using the miRNA microarray approach.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44453 | GEO | 2013/03/01

SECONDARY ACCESSION(S): PRJNA190011

REPOSITORIES: GEO

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MiRNA profiling in lung epithelial cells during infection with influenza A virus of H5N1 strain

Project description:This study aims at elucidating how H5N1 influenza infection perturbs the host's miRNA regulatory pathways that may lead to adverse pathological events, such as cytokine storm, using the miRNA microarray approach. The cell line - NCI-H292, was infected with various preparations of H5N1 influenza viruses was analysed for miRNA expression profiles subsequently. The miRNA expression profiles were measured at 3, 6, 18, and 24 hours post infection, respectively.

2013-03-01 | E-GEOD-44453 | biostudies-arrayexpress

MiRNA profiling in lung epithelial cells during infection with influenza A virus of H1N1 strain

2013-03-01 | GSE44452 | GEO

MiRNA profiling in lung epithelial cells during infection with influenza A virus of H1N1 strain

Project description:This study aims at elucidating how H1N1 influenza infection perturbs the host's miRNA regulatory pathways that may lead to adverse pathological events, such as cytokine storm, using the miRNA microarray approach. The cell line - NCI-H292, was infected with various preparations of H1N1 influenza viruses was analysed for miRNA expression profiles subsequently. The miRNA expression profiles were measured at 3, 6, 18, and 24 hours post infection, respectively.

2013-03-01 | E-GEOD-44452 | biostudies-arrayexpress

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Expression profile of lungs from two fatal H5N1 influenza cases

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microRNA (miRNA) expression profiling of A549 with H5N1 Influenza A Virus (hm/06)infection

Project description:To study miRNA expression profiles during highly pathogenic avian influenza virus infection, we conducted global miRNA expression profiling in human lung epithelial cells (A549) with or without H5N1 IAV infection. .

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Expression profile of lungs from two fatal H5N1 influenza cases

Project description:The pathogenesis of avian influenza A H5N1 virus in human has not been clearly elucidated. There have been increasing evidence suggesting a role for virus-induced cytokine dysregulation in contributing to the pathogenesis of human H5N1 disease. However, the role of aberrant innate immune response in human lungs infected by avian influenza H5N1 virus has not been explored and direct evidence for inappropriate innate responses in lungs of avian influenza H5N1 virus infected patients is lacking. In order to obtain evidences for the proposed role of aberrant innate immune response in avian influenza H5N1 virus pathogenesis in human, we analyzed expression profile of lung tissues from two fatal cases of avian influenza H5N1 virus infected patients in comparison to normal human lung using an expression microarray.

2010-06-16 | E-GEOD-22212 | biostudies-arrayexpress

MiRNA profiling in Rattus norvegicus pancreatic cells: INS-1E cells during infection with Coxsackie B4 virus

Project description:This study aims at elucidating how Coxsackie B virus infection perturbs the host's miRNA regulatory pathways that may lead to different pathological events using the miRNA microarray approach.

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MiRNA profiling in Rattus norvegicus pancreatic cells: RIN-5F cells during infection with Coxsackie B4 virus

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Gene expression analysis of chickens (Gallus gallus) infected with recombinant influenza viruses

Project description:H5N1 subtype highly pathogenic avian influenza virus has been spreading to Asia, Eurasia and African coutries. An original or six of recombinant H5N1 subtype influenza viruses with varying survivability were infected to chickens for elucidating genes correlated with pathogenicity.

2012-03-31 | GSE32378 | GEO

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