Expression data from wild-type and microRNA-155 (miR-155) deficient CD8 T cells

ABSTRACT: MicroRNA-155 (miR-155) is upregulated in primary effector CD8 T cells but is expressed at low amounts in naïve cells. Anti-viral CD8 T cell responses and viral clearance were impaired in miR-155 deficient (bic-/-) mice, and this defect was intrinsic to CD8 T cells, as adoptively transferred bic-/- CD8 T cells generated greatly reduced primary and memory responses during infection. To understand the mechanism by which miR-155 regulates CD8 T cell activation, we analyzed the gene expression profiles of naive and in vitro activated wild-type and bic-/- CD8 T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE44649 | GEO | 2013/02/26

SECONDARY ACCESSION(S): PRJNA190692

REPOSITORIES: GEO