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Genome-wide analysis of dFOXO binding sites in Drosophila

ABSTRACT: To understand how reduced insulin/IGF-1 signaling extends Drosophila lifespan through its downstream transcription factor dFOXO. We conducted ChIP analysis with a dFOXO antibody followed by Illumina high-throughput sequencing from chico heterozygous mutants, which are long-lived and normal sized, and from adult flies with ablated insulin producing cells (IPCs), which are also long-lived. dFOXO bound at promoters of 273 genes common among these genotypes, thus potentially enriching for shared factors in control of aging.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE44686 | GEO | 2013/09/20

SECONDARY ACCESSION(S): PRJNA191574

REPOSITORIES: GEO

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Genome-wide analysis of dFOXO binding sites in Drosophila

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