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Cancer-related epigenome changes among induced pluripotent stem cell lines

ABSTRACT: To identify hypermethylated genes in induced pluripotent stem cell lines, human embryonic stem cell lines, and non-nucleofected CD34+ CB cells, indicated cell lines were treated with 5-aza-2′-deoxycytidine (DAC) or trichostatin A (TSA), and drug-induced changes in gene expression vs control treatment (PBS) were identified using Agilent two-color arrays, using the experimental methods of Ohm et al. (Cancer Res 70:7662-7673 2010).

ORGANISM(S): Homo sapiens

PROVIDER: GSE44941 | GEO | 2017/12/31

SECONDARY ACCESSION(S): PRJNA192592

REPOSITORIES: GEO

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