Identification of novel copy number alterations by high-resolution aCGH from FFPE cutaneous melanoma samples

ABSTRACT: We investigated a cohort of 34 archival cutaneous melanoma samples by Agilent 40 kb-resolution CGH array. We found a non-random distribution of precise CNAs predictive for clinical outcome. Although most of the alterations defined in this study have been already reported, we mapped novel melanoma-specific CNAs at highest accuracy. Moreover, our data revealed distinct amplifications hotspots, some of which were validated by quantitative real-time PCR, enabling the identification of novel melanoma oncogenic candidates. Keywords: Cutaneous melanoma, Copy number alterations, Biomarkers, FFPE

ORGANISM(S): Homo sapiens

PROVIDER: GSE45354 | GEO | 2013/07/01

SECONDARY ACCESSION(S): PRJNA193525

REPOSITORIES: GEO