Transcriptomics

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Gene expression analysis to identify Runx1 target genes in B-cell progenitors


ABSTRACT: The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .

ORGANISM(S): Mus musculus

PROVIDER: GSE45424 | GEO | 2013/05/27

SECONDARY ACCESSION(S): PRJNA193698

REPOSITORIES: GEO

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