Directed differentiation of human pluripotent stem cells into cortical interneurons

ABSTRACT: Here we demonstrate the highly efficient derivation of human cortical interneurons in a NKX2.1::GFP hESC reporter line. Manipulating the timing of SHH activation yields three distinct GFP+ populations with specific transcriptional profiles, neurotransmitter phenotypes and migratory behaviors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46098 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA197259

REPOSITORIES: GEO