Transcriptomics comparisons of Mac-T cells versus mammary tissue during late pregnancy and peak lactation

ABSTRACT: The bovine mammary epithelial cell line Mac-T has been used to study mammary gland in vitro. The reliability of this system to study mammary gland has not been tested using genomics approaches. In the present experimetn a direct transcriptomics comparison between Mac-T cells and mammary tissue at -30 and at 60 day in milk (DIM) is performed. Data indicated that Mac-T cells and mammary tissue had a substantially different transcriptome with a larger difference between Mac-T cells and lactating mammary tissue (i.e., 60 DIM) compared to non-lactating mammary tissue (i.e., -30 DIM). In addition, data indicated that the Mac-T cells substantially differ with mammary tissue in lactation-specific functions.

ORGANISM(S): Bos taurus

PROVIDER: GSE46476 | GEO | 2013/04/30

SECONDARY ACCESSION(S): PRJNA200589

REPOSITORIES: GEO