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Transcriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo

ABSTRACT: Analysis of the specific transcriptional changes on DCs provided by direct pattern recogition receptor (PRR) or IFNAR signaling that are required for DC maturation after poly IC stimulation. Results provide important information about the intricate differentiation process of DC maturation and the importance of type I IFNs for DC immunogenicity.

ORGANISM(S): Mus musculus

PROVIDER: GSE46478 | GEO | 2013/10/01

SECONDARY ACCESSION(S): PRJNA200593

REPOSITORIES: GEO

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Transcriptional profile of WT, PRR and IFN-/- dendritic cells stimulated with poly IC in vivo

Project description:Analysis of the specific transcriptional changes on DCs provided by direct pattern recogition receptor (PRR) or IFNAR signaling that are required for DC maturation after poly IC stimulation. Results provide important information about the intricate differentiation process of DC maturation and the importance of type I IFNs for DC immunogenicity. WT/IFNA-/- or WT/PRR-/- mixed-chimera mice were injected with 50 ug Poly-IC i.p. in vivo 4 and 14 hr later, wild type and KO CD11chi CD3- DX5- B220- DCs were FACS sorted based on CD45.2 expression. Total RNA was isolated and expression profile was compared between unstimulated and activated WT and KO DCs.

2013-10-01 | E-GEOD-46478 | biostudies-arrayexpress

NOTCH3-IC

Project description:NOTCH3-IC

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Transcription profiling of human time points after induction of Notch1-IC, Notch2-IC or EBNA2 in EREB2-5 cells - detection of Notch1-IC, Notch2-IC and EBNA2 target genes in human B cells

Project description:Notch1-IC, Notch2-IC or EBNA2 have been induced in a conditionally immortalized human B cell line (EREB2-5) in order to identify similar and unique target genes in B cells. CAT was used as a control. Experiment Overall Design: RNA was isolated at different time points after induction of Notch1-IC, Notch2-IC or EBNA2 in EREB2-5 cells. Three independent experiments were performed (except Notch1-IC at 3day).

2009-08-25 | E-GEOD-12355 | biostudies-arrayexpress

Detection of Notch1-IC, Notch2-IC and EBNA2 target genes in human B cells

2009-08-06 | GSE12355 | GEO

Human dermal endothelial cells co-treated with dsRNA mimic poly IC and antimicrobial peptide LL-37

Project description:Next generation sequencing (RNA-seq) was used to study the global effects of co-treatment of endothelial cells with poly IC and LL-37. This lead to identification of differentially regulated genes and enriched pathways

2019-04-02 | GSE129152 | GEO

IC - Experiment 3

Project description:Cells from 6 different IC patients were run in parallel with cells from their 6 different matched controls. Keywords: other

2003-07-14 | GSE347 | GEO

IC - Experiment 2

Project description:Normal bladder epithelial cell explants from 2 different normal controls were treated with APF from 2 different IC patients or mock APF from 2 different matched controls. Keywords: other

2003-07-14 | GSE346 | GEO

IC - Experiment 1

Project description:Normal bladder epithelial cell explant from a single normal control was treated with APF from a single IC patient or mock APF. Two different membranes were used. Keywords: other

2003-07-14 | GSE345 | GEO

Transcription profiling of primary human astrocytes from brain treated by stathmin, poly IC and ultrapure LPS to examine the effects of different Toll-like receptor agonists

Project description:Goal of the experiment was to examine the effects of different Toll-like receptor agonists on the human astrocyte response, in termsof levels of transcripts encoding cytokines, chemokines and theirreceptors. Stathmin and poly IC are considered as agonist for TLR3, LPSas an agonist for TLR4. The manuscript we are about to submit to Journal of Immunology contains these data, and identifies stathmin, aprotein, as a novel TLR3 agonist. We all know that poly IC is, and bycomparing the transcript responses in astrocytes to either poly IC andstathmin, and observing the similarity in these responses, the experiment adds to the evidence that stathmin indeed activates a verysimilar cellular response as poly IC. The LPS-induced response,mediated by TLR4, is included as a reference, to illustrate thatanother TLR-mediated reaction produces quite something different.

2010-02-11 | E-TABM-851 | biostudies-arrayexpress

Peptidomics analysis of urine from IC/BPS patients and healthy controls

Project description:Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood etiology. A definitive diagnosis of IC/BPS can be challenging because many symptoms of IC/BPS are shared with other urological disorders. An analysis of urine presents an attractive and non-invasive resource for monitoring and diagnosing IC/BPS. Here, a non-targeted LC-MS and LC-MS/MS-based peptidomics analysis of urine samples collected from IC/BPS patients were compared to urine samples from asymptomatic controls.

2022-06-06 | PXD031843 | Pride

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