Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Peripheral blood mononuclear cell (PBMC) gene expression in healthy adults rapidly transported to high altitude

ABSTRACT: Differential expression analysis comparing healthy volunteers at sea level and after acute exposure to altitude

ORGANISM(S): Homo sapiens

PROVIDER: GSE46480 | GEO | 2013/04/30

SECONDARY ACCESSION(S): PRJNA200623

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Peripheral blood mononuclear cell (PBMC) gene expression in healthy adults rapidly transported to high altitude

Project description:Differential expression analysis comparing healthy volunteers at sea level and after acute exposure to altitude PBMCs were isolated from healthy volunteers participating in the United States Antarctic Program. Array data was processed using the Affymetrix HG U133 Plus 2 array

2013-04-30 | E-GEOD-46480 | biostudies-arrayexpress

Gene expression profiling under exposure to high altitude hypoxic environment

Project description:Understanding molecular mechanism associated with high altitude exposure during acclimatization/adaptation/maladaptation. Data reveals specific components of the complex molecular circuitry underlying high altitude pulmonary edema. Individualized outcome prediction were constructed through expression profiling of 39400 genes in sea level sojourners who were acclimatized to high altitude and grouped as controls (n=14), high altitude natives (n=14) and individuals who developed high altitude pulmonary edema within 48-72 hours after air induction to high altitude (n=17).

2013-12-18 | E-GEOD-52209 | biostudies-arrayexpress

Transcriptome signature of local native cattle of Ladakh region from high altitude and Sahiwal cattle from low altitude (sea level).

Project description:The transcriptome signature of peripheral blood mononuclear cells (PBMCs) of Ladakhi cattle adapted to high altitude vis a vis Sahiwal cattle adapted to the arid/semi-arid region at mean sea level was established using bovine expression microarray chips. The transcriptome analysis of PBMCs from these cattle types living at two distinct altitudes, resulted in identification of several hundred differentially expressed genes, biological processes, molecular functions and pathways.

2021-07-09 | GSE116800 | GEO

Intermittent Hypoxia Alters Gene Expression in Peripheral Blood Mononuclear Cells (PBMC) of Healthy Volunteers

Project description:Intermittent hypoxia (IH) of obstructive sleep apnea (OSA) has been implicated in cardiovascular morbidity and mortality1. Although underlying mechanisms of the cardiovascular risk in OSA are not well defined, experiments in cell culture and animal models suggest that IH up-regulates pro-inflammatory genes that can promote atherosclerosis and insulin resistance. We hypothesized that short-term IH (5 h) will induce pro-inflammatory genes in healthy volunteers

2015-07-27 | GSE71356 | GEO

Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats

Project description:High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease caused by chronic hypoxia and subsequent pulmonary vascular remodeling. No cure is currently available owing to an incomplete understanding about vascular remodeling. It is believed that hypoxia-induced diseases can be prevented by treating hypoxia. Thus, this study aimed to determine whether daily short-duration reoxygenation at sea level attenuates pulmonary hypertension under high-altitude hypoxia. To this end, a simulated 5,000-m hypoxia rat model was used to evaluate the effect of short-duration reoxygenation. Results show that intermittent, not continuous, short-duration reoxygenation effectively attenuates hypoxia-induced pulmonary hypertension. The mechanisms underlining the protective effects involved that intermittent, short-duration reoxygenation prevented functional and structural remodeling of pulmonary arteries and proliferation, migration, and phenotypic conversion of pulmonary artery smooth muscle cells under hypoxia. The specific genes or potential molecular pathways responsible for mediating the protective effects were also characterised by RNA sequencing.This study is novel in revealing a new potential method in preventing high-altitude pulmonary hypertension. It gives insights into the selection and optimisation of oxygen supply schemes in high-altitude areas.

2020-11-06 | GSE160926 | GEO

Comparative transcriptomic analysis provides insights into high-altitude adaptation

Project description:Purpose: High-altitude adaptive evolution of transcription, and the convergence and divergence of transcriptional alteration across species in response to high-altitude environments, is an important topic of broad interest to the general biology community. Our study aims to answer this important biological question. Methods: We generated deep transcriptome data of high- and low- altitude populations across four species: chicken, pig, goat and sheep, as well as high-altitude yak and low-altitude cattle, from six tissues (heart, kidney, liver, lung, skeletal muscle and spleen). Results: Here we provide a comprehensive comparative transcriptome landscape of expression and alternative splicing variation between low- and high-altitude populations across multiple species for distinct tissues. Conclusions: Our data serves a valuable resource for further study on adaptive transcription evolution and identification of candidate adaptive genes.

2017-09-06 | GSE93855 | GEO

Circulating microRNAs reprogramming are involved in early acclimatization to high altitude in humans

Project description:Altitude acclimatization is the physiological process to restore oxygen delivery to the tissues and promote the oxygen application under high altitude hypoxia. High altitude illness could happen in individuals who did not get acclimatization. Unraveling the molecular underpinnings of altitude acclimatization would help people to understand the beneficial response of body to high altitude hypoxia and disturbed biological process in un-acclimatized individuals. Here, we measured physiological adjustments and circulating microRNAs (cmiRNAs) profiles of individuals exposed to high altitude to explore the altitude acclimatization in humans.

2017-02-09 | GSE89486 | GEO

Moderate hypoxia influence at intermediate altitude in Argentinean Andes

Project description:This study evaluates genetic and phenotypic variation in the intermediate altitude CalchaquÃ population living in the CalchaquÃ Valleys of the Argentinean Andes in the town of Cachi at 2300 m. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to moderate hypoxia at a intermediate altitude. DNA from 24 saliva samples of CalchaquÃes living at 2300 m in Cachi in the Province of Salta in Argentina was genotyped.

2014-04-05 | E-GEOD-56518 | biostudies-arrayexpress

Plasma proteomics analysis of individuals at high altitude and sea level revealed by LC-MS/MS

Project description:We aim to investigate the changes of plasma proteome between sea level and high altitude, between AMS patients and non-AMS controls.

2023-09-21 | PXD045131 | iProX

Next generation sequencing for temporal analysis at high altitude in Indian and Kyrgyz healthy males

Project description:Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The aim of the study is to analyse the time series analysis at high altitude to dynamically capture the complete drift impringes in humans and specific selection of decisive time point for therapeutic interventions.

2020-06-27 | GSE133702 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data