Expression data from NRK-52E cells treated with chlorothalonil for 6h, 24h and 72h.

ABSTRACT: Chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) is a widely used broad spectrum fungicide. Despite its common use, chlorothalonil is classified by IARC as Group 2B, a possible human carcinogen, with formation of renal tubular adenomas and carcinomas in rats of both sexes and in male mice. In this study we have examined the effect of sub-cytotoxic exposure to chlorothalonil at 6h, 24h and 72h on the whole-genome expression profile in a rat proximal renal tubule cell line (NRK-52E). We used microarrays to detail the mechanism of toxicity and possibly carcinogenicity.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE46852 | GEO | 2020/09/20

REPOSITORIES: GEO