Dataset Information


B.thetaiotaomicron wt versus KO3172, PR chow, NMRI

ABSTRACT: Genome wide trascriptional comparison of B. thetaiotaomicron wild-type vs. an isogenic mutant (BT3172::pGERM). Cecal populations of wt or BT3172::pGERM monoassociated 10d with NMRI gnotobiotic mice fed a standard-chow polysaccharide rich (PR) diet (n=5 samples/group) were profiled. Keywords: Wild-type versus Knockout, in vivo Overall design: Total RNA was prepared from cecal contents of 10 day monoassociated gnotobiotic mice and hybridized to B. thetaiotaomicron GeneChips.

INSTRUMENT(S): bthetaa511044F

SUBMITTER: Justin L. Sonnenburg  

PROVIDER: GSE4703 | GEO | 2006-05-14



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A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism.

Sonnenburg Erica D ED   Sonnenburg Justin L JL   Manchester Jill K JK   Hansen Elizabeth E EE   Chiang Herbert C HC   Gordon Jeffrey I JI  

Proceedings of the National Academy of Sciences of the United States of America 20060530 23

Bacteroides thetaiotaomicron is a prominent member of our normal adult intestinal microbial community and a useful model for studying the foundations of human-bacterial mutualism in our densely populated distal gut microbiota. A central question is how members of this microbiota sense nutrients and implement an appropriate metabolic response. B. thetaiotaomicron contains a large number of glycoside hydrolases not represented in our own proteome, plus a markedly expanded collection of hybrid two-  ...[more]

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