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Differential gene expression in peripheral blood leukocytes from mice subject to repeated social defeat

ABSTRACT: This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood mononuclear cells (PBMC), and examined the extent to which these effects were abrogated by depletion of CD11b+ cells (monocytes). Study Type: Risk prediction

ORGANISM(S): Mus musculus

PROVIDER: GSE47154 | GEO | 2013/11/04

SECONDARY ACCESSION(S): PRJNA204591

REPOSITORIES: GEO

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Differential gene expression in peripheral blood leukocytes from mice subject to repeated social defeat

Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood mononuclear cells (PBMC), and examined the extent to which these effects were abrogated by depletion of CD11b+ cells (monocytes). Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood mononuclear cell (PBMC) mRNA samples collected from 18 mice randomized to either 6 cycles of repeated social defeat (RSD, n=9) or to home cage control (HCC, n=9) conditions. PBMC samples were pooled into 3 groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on approximately 1 million total PBMC and 1 million PBMC from which CD11b+ cells were immunomagnetically depleted by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether depletion of CD11b+ cells (monocytes) abrogates these effects.

2013-11-04 | E-GEOD-47154 | biostudies-arrayexpress

Effect of propranolol on differential gene expression in peripheral blood monocytes from mice subject to repeated social defeat

Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood monocytes and examined the extent to which these effects were abrogated by the beta-adrenergic antagonist propranolol. Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood monocyte mRNA samples collected from 36 mice randomized to either 6 cycles of repeated social defeat (RSD, n=18) or to parallel home cage control (HCC, n=18) conditions. Within each condition (RSD vs HCC), 9 animals were treated with the beta-adrenergic antagonist propranolol and 9 were treated with an equivalent volume of vehicle. After 6 cycles of RSD or parallel HCC, blood samples were pooled into groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on RNA from approximately 1 million CD11b+ peripheral blood mononuclear cells (i.e., monocytes) which were immunomagnetically isolated by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether treatment with propranolol abrogates these effects.

2013-11-04 | E-GEOD-47153 | biostudies-arrayexpress

Effect of propranolol on differential gene expression in peripheral blood monocytes from mice subject to repeated social defeat

2013-11-04 | GSE47153 | GEO

Microglial RNA-sequencing after stress-sensitization by repeated social defeat

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Effects of social defeat stress on colonic epithelial transcriptome

Project description:This study assessed the effects of social defeat stress on the murine colonic epithelial transcriptome

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Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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Gene expression alteration in the hippocampus of depression mouse model with repeated social defeat stress

Project description:We used microarrays to identify the gene with altered expression in the hippocampus of depression mouse model with repeated social defeat stress campared to control mice.

2023-02-17 | GSE218742 | GEO

The effect of Repeated Social defeat stress (RSD) on transcriptomic profiles of rat heart

Project description:This study investigated risk factors that may contribute to stress-related cardiac disease susceptibility and progression in a rodent model. The experiment was designed to evaluate the transcriptomic changes in in the heart of male adult rats after repeated episodes of social defeat stress.

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