Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from adult Drosophila females [normoxia and IH]

ABSTRACT: High-fat diet (HFD) in normoxia causes a worsened phenotype in adult female flies compared to regular diet (RD). Intermittent hypoxia (IH) causes an opposite phenotype both when flies are on RD in IH compared to normoxia and even more dramatically when on HFD in IH compared to HFD in normoxia. We used microarrays to examine the transcriptional changes occurring both on a HFD compared to RD in normoxia, and when IH is introduced.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE47166 | GEO | 2015/05/30

SECONDARY ACCESSION(S): PRJNA204968

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data from adult Drosophila females [normoxia]

Project description:High-fat diet (HFD) in normoxia causes a worsened phenotype in adult female flies compared to regular diet (RD). We used microarrays to examine the transcriptional changes occuring on a HFD compared to RD in normoxia. Adult female Drosophila were collected at d3-5 and placed on RD or HFD and in normoxia for 1 week. Following this week,flies were immediately frozen on dry ice, RNA was extracted and hybridized on Affymetrix microarrays.

2014-02-04 | E-GEOD-46358 | biostudies-arrayexpress

Expression data from adult Drosophila females [normoxia]

2014-02-04 | GSE46358 | GEO

Global chromatin accessibility using an Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq) reveals epigenomic reprogramming of Adipose tissue macrophages toward proinflammatory and proangiogenic phenotypes in formerly obese mice.

Project description:We report sustained changes in the chromatin accessibility landscape of adipose tissue macrophages (ATMs) from high fat diet (HFD)-fed mice persist long after return to regular diet (RD). We compared the data of ATAC-seq performed on nuclei extracted from FACS-sorted ATMs isolated from HFD, RD-RD and HFD-RD-fed mice. Inter-group comparisons revealed the highest diversity and hence the greatest number of differentially accessible regions (DARs) to occur between ATMs from RD-RD and HFD-RD-fed mice, and considerably fewer DARs were identified between ATMs from HFD-RD vs HFD-fed mice. Association of DARs with the nearest gene and gene ontology (GO) enrichment analysis revealed considerable pathway enrichment, especially pathways coding for angiogenesis and inflammatory response, in HFD-RD group when compared to RD-RD group. The results altogether indicated that most changes in chromatin landscape induced by HFD-feeding are maintained as open chromatin positions for a long time, suggesting that HFD-feeding leads to long-term reprograming of ATMs and renders them prone to pro-angiogenic and pro-inflammatory responses.

2024-01-25 | GSE175614 | GEO

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice

Project description:We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome. HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND).

2019-11-19 | GSE140389 | GEO

Gender-specific transcriptomic changes with high fat diet

Project description:we investigated the effect of HFD on the transcriptome in the heads and bodies of male and female flies kept on either HFD or regular diet (RD). Using comprehensive genomic analyses which include high-throughput transcriptome sequencing, pathway enrichment and gene network analyses, we found that HFD induces a number of responses that are sexually dimorphic in nature. There was a robust transcriptional response consisting of a downregulation of stress-related genes in the heads and glycoside hydrolase activity genes in the bodies of males. In the females, the HFD led to an increased transcriptional change in lipid metabolism.

2019-01-31 | GSE123240 | GEO

Gene expression profiling from high-fat diet (HFD)-treated and regular diet (RD)-treated lung cancer

Project description:We utilized inducible transgenic mouse with spontaneous lung cancer formation driven by mutant EGFR (by Doxycycline induction) for experiments. Mice fed with regular diet (RD) or high-fat diet (HFD) were induced lung cancer followed by tumor burden evaluation. Lung tissues were harvested for whole-genome transcriptomic, gene enrichment analysis, and cytokine array for potential signatures identification.Gene set enrichment analysis showed the whole-genome transcriptome in HFD vs. RD treated lung cancer was enriched in immune responses and cytokine stimulus.

2018-09-08 | GSE119649 | GEO

microRNA expression in infantile hemangioma (IH) and normal skin tissues

Project description:To determine the microRNA expression profile in IH and non-tumor tissues, we uesed miRNA 4.0 microarray form Affymetrix to examine the expression of microRNA in IH and non-tumor tissues

2020-06-06 | GSE100682 | GEO

circRNA expression in infantile hemangioma (IH) and matched non-tumor tissues

Project description:To determine the circRNA expression profile in IH and matched non-tumor tissues, we uesed circRNA microArray analysis form Arraystar to examine the expression of circRNAs in IH and matched non-tumor tissues.

2019-05-09 | GSE98795 | GEO

Transcription profiling of human myeloma cell line IH-1 response to BMP-4

Project description:The IL-6-dependent human myeloma cell line IH-1 was stimulated with BMP-4 (50 ng/ml) for four hours and compared to control cells.

2004-09-01 | E-MEXP-124 | biostudies-arrayexpress

Weight loss resulted in increased expression of the anti-inflammatory protein, CRISPLD2, in mouse adipose tissue

Project description:Purpose: NGS was used to determine if a distinct transcriptomic profile is observed between lean, obese and weight loss fat Methods: We carried out RNA-Seq analysis of epididymal adipose mice ad libitum fed for 10 weeks either a high fat diet (HFD) or a regular chow diet (RD), versus a cohort of mice fed HFD for the first 5 weeks before swapping to RD for the remainder (SWAP). Results: SWAP feeding resulted in weight loss with a parallel improvement in insulin sensitivity. RNA-Seq revealed several transcriptomic signatures distinct to SWAP adipose, distinguished from both RD and HFD adipose. We found a unique up-regulated mRNA encoding a secreted, LPS-binding glycoprotein, CRISPLD2, in SWAP adipose tissue. While cellular CRISPLD2 protein levels were unchanged, plasma CRIPSLD2 levels increased in SWAP mice following weight loss, and can correlate with insulin sensitivity. Conclusions: Taken together, our data demonstrate that CRISPLD2 is a circulating adipokine that may regulate adipocyte remodeling during weight loss.

2019-08-02 | GSE135239 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data