Transcriptomics

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Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer

ABSTRACT: A bank of human breast tumor xenografts was established by serial passage of primary breast tumor fragments in the cleared mammary fat pads of immuno-compromised NOD-SCID-IL2Rgammac-/- mice. The expression profiles from four different tumors (23T, 315T, 50T and 838T) were classified using diagonal discriminant analysis. The training data set consisted of 1992 samples from Curtis et al. (2012, PMID: 22522925); class labels were based on tumor subtype information provided (Basal-like, Luminal A, Luminal B, HER2-enriched and Normal breast-like).

ORGANISM(S): Homo sapiens

PROVIDER: GSE47369 | GEO | 2013/06/09

SECONDARY ACCESSION(S): PRJNA205300

REPOSITORIES: GEO

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