Genomics

Dataset Information

39

Study of the onset of puberty in the European sea bass


ABSTRACT: Pubertal development in males starts with the onset of spermatogenesis that implies the division of primary spermatogonia and their subsequent entry into meiosis. Whole genome microarray expression profile was used as a means to explore the molecular basis underlying the onset of pubertal development in sea bass. The present study is aimed at the characterization of the expression of genes involved in the onset of spermatogenesis in the European sea bass. The study is focused on the first stages of the process including the appearance of spermatocytes and thus the first meiotic divisions. The transcriptomic study using a sea bass-specific microarray resulted in a number of genes differentially expressed during the onset of spermatogenesis. Among those, genes involved in cell-cycle progression, microtubule assembly during meiosis or retinoic acid signaling pathway indicating that they can be used as potential molecular markers for the onset of spermatogenesis in sea bass. Overall design: Two different experimental groups (conditions) were used in the study. Condition 1 corresponded to testicular development stage I, whereas condition 2 represented testicular development stage II. Both conditions were compared to reveal differences in gene expression signatures related to the onset of spermatogenesis.

INSTRUMENT(S): Dicentrarchus labrax oligonucleotide-microarray (LOQ)

ORGANISM(S): Dicentrarchus Labrax

SUBMITTER: Mercedes Blazquez  

PROVIDER: GSE47400 | GEO | 2017-06-23

SECONDARY ACCESSION(S): PRJNA205473

REPOSITORIES: GEO

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Publications

Identification of conserved genes triggering puberty in European sea bass males (Dicentrarchus labrax) by microarray expression profiling.

Blázquez Mercedes M   Medina Paula P   Crespo Berta B   Gómez Ana A   Zanuy Silvia S  

BMC genomics 20170605 1


<h4>Background</h4>Spermatogenesis is a complex process characterized by the activation and/or repression of a number of genes in a spatio-temporal manner. Pubertal development in males starts with the onset of the first spermatogenesis and implies the division of primary spermatogonia and their subsequent entry into meiosis. This study is aimed at the characterization of genes involved in the onset of puberty in European sea bass, and constitutes the first transcriptomic approach focused on mei  ...[more]

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