Genomics

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Expression data from bone marrow macrophage derived from lean and obese mice after 1,4, and 24h exposition to P.gingivalis


ABSTRACT: Obesity is a chronic inflammatory disease that weakens macrophage innate immune response to infections. Since M1 polarization is crucial during acute infectious diseases, we hypothesized that diet-induced obesity inhibits M1 polarization of macrophages in the response to bacterial infection. Using a computational approach in conjunction with microarray data, we identified switching genes that may differentially control the behavior of response pathways in macrophages from lean and obese mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE47414 | GEO | 2013/06/12

SECONDARY ACCESSION(S): PRJNA205528

REPOSITORIES: GEO

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