Expression data from immortalized human lung small airway epithelial cells

ABSTRACT: In lung cancer progression, p53 mutations are more often observed in invasive tumors than in non-invasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor, it is crucial to elucidate the detailed mechanism of the alteration in epithelial cells, the main origin of solid tumors, following p53 inactivation. To elucidate the mechanism by which p53 loss enhances invasive and motile activities in human lung small airway epithelial cells (SAECs), we performed comprehensive expression profiling analyses between p53 knockdown and control cells using GeneChip Human Genome U133 plus 2.0 arrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE47436 | GEO | 2013/05/29

SECONDARY ACCESSION(S): PRJNA205559

REPOSITORIES: GEO