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Induction of pluripotency in mouse somatic cells with lineage specifiers (RNA-seq)

ABSTRACT: For years, reprogramming factors that induce pluripotency have been identified primarily from ESC-enriched factors, pluripotency-associated factors such as Oct4, Sox2, Klf4, c-Myc, Nanog, Esrrb, Sall4, Utf1, Lin28, PRDM14, and Tet2. Through genome-wide screen we identified novel regulators of reprogramming. Our study is the first proof-of-principle report to suggest a putative general "seesaw model". This model provides novel mechanistic insight into the fundamental understanding of the establishment of cellular identity during programming and reprogramming.

ORGANISM(S): Mus musculus

PROVIDER: GSE47442 | GEO | 2013/05/28

SECONDARY ACCESSION(S): PRJNA205931

REPOSITORIES: GEO

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Induction of pluripotency in mouse somatic cells with lineage specifiers (RNA-seq)

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