Genomics

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Changes in mouse kidney glomerular gene expression following dendrin knockout


ABSTRACT: Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. The highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. Dendrin is a poorly characterized cytosolic component of the slit diaphragm in where it interacts with nephrin and Cd2ap. In this study, we have generated a dendrin knockout mouse line and explored the molecular interactions of dendrin. Dendrin-deficient mice were viable, fertile and had normal life span. To reveal the glomerular gene expression changes in the dendrin knockout mouse, Affymetrix Mouse Genome 430 2.0 Array were used to profiling the dendrin knockout and control glomeruli.

ORGANISM(S): Mus musculus

PROVIDER: GSE47606 | GEO | 2014/05/20

SECONDARY ACCESSION(S): PRJNA206505

REPOSITORIES: GEO

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