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Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

ABSTRACT: Genome-wide gene expression analysis on tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype.

ORGANISM(S): Mus musculus

PROVIDER: GSE47801 | GEO | 2013/09/23

SECONDARY ACCESSION(S): PRJNA207822

REPOSITORIES: GEO

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Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

Project description:Genome-wide gene expression analysis on tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype. Total RNA was obtained from biological triplicates of tibialis anterior muscle from 2-month-old nebulin SH3 domain deleted (Neb∆SH3) mice compared to wildtype.

2013-09-23 | E-GEOD-47801 | biostudies-arrayexpress

Mus musculus

Project description:Genome-wide gene expression analysis on tibialis anterior muscle from nebulin SH3 domain deleted (Neb∆SH3) mice

| PRJNA207822 | ENA

The effect of Nebulin-Deficiency on Skeletal Muscle

Project description:Nebulin is a giant filamentous protein that is coextensive with the actin filaments of the skeletal muscle sarcomere. Nebulin mutations are the main cause of nemaline myopathy (NEM), with typical NEM adult patients having low expression of nebulin, yet the roles of nebulin in adult muscle remain poorly understood. To establish nebulin’s functional roles in adult muscle we performed studies on a novel conditional nebulin KO (Neb cKO) mouse model in which nebulin deletion was driven by the muscle creatine kinase (MCK) promotor. Neb cKO mice are born with high nebulin levels in their skeletal muscle but within weeks after birth nebulin expression rapidly falls to barely detectable levels Surprisingly, a large fraction of the mice survives to adulthood with low nebulin levels (<5% of control), contain nemaline rods, and undergo fiber-type switching towards oxidative types. These microarrays investigate the changes in gene expression when nebulin is deficient.

2015-06-25 | GSE70213 | GEO

The effect of Nebulin-Deficiency on Skeletal Muscle

2015-06-25 | E-GEOD-70213 | biostudies-arrayexpress

RNA-seq of wild-type and mfn1-/-,mfn2-/- tibialis anterior muscle (mouse).

Project description:We report the transcriptome changes in tibialis anterior muscle in response to deletion of the Mfn1 and Mfn2 genes.

2022-03-14 | GSE198071 | GEO

Expression data from tibialis anterior muscle

Project description:We generated transgenic mice expressing constitutively SOCS-3 specifically in skeletal muscle. SOCS proteins are implicated in the negative regulation of various pathways including insulin signaling pathway. Our transgenic mice are predisposed to obesity and systemic insulin resistance compared to control mice. We used microarrays to detail the variations of gene expression in muscle from transgenic mice versus controls. Keywords: transgenic, tibialis anterior, SOCS-3

2009-03-01 | GSE11105 | GEO

Analysis of tibialis anterior muscle post-injection with nanoparticles in mice

Project description:Proteomic study of tibialis anterior muscle harvested at 1 day and 7 days post-injection with novel polyurethane nanoparticles compared to water sham and non-injected controls

2021-03-12 | MSV000087040 | MassIVE

Tibialis anterior muscle of myostatin null mice treated with clenbuterol

Project description:Transcription profiling of skeletal muscle (tibialis anterior) of 5-week-old male wild type and myostatin null mice given ad libitum access to 20ppm clenbuterol hydrochloride in drinking water or plain tap water for 2 weeks. The objective of the study was to determine overlap in the mechanisms of muscle hypertrophy of the two models.

2014-02-03 | GSE27577 | GEO

Transcription profiling of mouse masseter and tibialis anterior muscles to determine expression differences between muscle groups

Project description:Masseter and Tibialis anterior muscles from adult female control mice to determine expression differences between muscle groups

2007-10-11 | E-MEXP-1288 | biostudies-arrayexpress

Tibialis anterior muscle of myostatin null mice treated with clenbuterol

2014-02-03 | E-GEOD-27577 | biostudies-arrayexpress

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