Dataset Information


Global epigenomic reconfiguration during mammalian brain development

ABSTRACT: Whole-genome single-base resolution methylcytosine and hydroxymethylcytosine maps reveal profound changes that occur during frontal cortex development in humans and mice. Overall design: MethylC-Seq, TAB-Seq, RNA-Seq and hmC-IP (CMS-IP and biotin-glucosyl tagging) from Homo sapiens and Mus musculus frontal cortex tissue and neural sorted cell populations. Additionally, MethylC-Seq was performed on the HUES6 embryonic stem cell line (Homo sapiens).

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Joseph R Ecker  

PROVIDER: GSE47966 | GEO | 2013-07-03



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DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, b  ...[more]

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