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Late life rapamycin treatment reverses age-related heart dysfunction

ABSTRACT: We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly differentially expressed genes between the control fed group and the Rapamycin diet group by our analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE48043 | GEO | 2013/07/01

SECONDARY ACCESSION(S): PRJNA208747

REPOSITORIES: GEO

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Late life rapamycin treatment reverses age-related heart dysfunction

Project description:We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly differentially expressed genes between the control fed group and the Rapamycin diet group by our analysis. Heart tissue samples from age-matched control mice (n=10) and rapamycin fed mice (n=10) were extracted for total RNA. The samples were sequenced using Illumina HiSeq 2000 (50 basepair paired-end sequencing). The sequencing yielded quality scores greater than 30 with an average of 10 million reads per sample. 34,293 genes were mapped back to the MGSCv37 C57BL/6J mouse genome (maximum paired distance=300 and minimum=130, minimum number of reads per mapping = 5, maximum number of mismatches= 2, with the reads being mapped to unique sites in the genome).

2013-07-01 | E-GEOD-48043 | biostudies-arrayexpress

The effect of short term Rapamycin on the transcriptome of old mouse liver

Project description:Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age.

2014-02-07 | GSE48331 | GEO

The effect of chronic Rapamycin on the transcriptome of old mouse liver

Project description:Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age.

2014-02-07 | GSE48333 | GEO

The mTOR pathway is necessary for survival of mice with short telomeres.

Project description:Gene expression profiles of Terc+/+ and generation 2 (G2) Terc-/- male mice fed rapamycin or control diet during 2 months. Rapamycin diet contains encapsulated rapamycin at 42 ppm (mg of drug per kg of food); control diet contains coating material (Eudragit S100). Rapamycin was microencapsulated by Rapamycin Holdings Inc. (San Antonio, Texas) and was then incorporated into 5LG6 mouse chow (TestDiet, London, UK).

2020-01-02 | GSE127475 | GEO

The effect of short term Rapamycin on the transcriptome of old mouse liver

Project description:Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age. Total RNA extracted from livers of 25 month old C57BL6/N male and female mice started on control or 14 ppm rapamycin (Rapa) from 19 months of age on 6 months of treatment. Number of samples total: 42, with 10 samples in Control males, 12 samples in Rapa males, 9 samples in Control Females, and 11 samples in Rapa Females

2014-02-07 | E-GEOD-48331 | biostudies-arrayexpress

The effect of chronic Rapamycin on the transcriptome of old mouse liver

Project description:Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age. Total RNA extracted from livers of 25 month old C57BL6/J male and female mice started on control or 14 ppm rapamycin (Rapa) from 4 months of age on 21 months of treatment. Number of samples total: 69, with 19 samples in Control males, 13 samples in Rapa males, 16 samples in Control Females, and 21 samples in Rapa Females

2014-02-07 | E-GEOD-48333 | biostudies-arrayexpress

RNA sequencing of liver and kidney tissues from mice treated with rapamycin during development

Project description:RNA sequencing of mouse liver and kidney. UMHET pups were treated with diet containing encapsulated rapamycin or encapsulating material as a control from birth to 45 days of age, and tissues were collected at 2, 20-22 and 27-29 months of age from both males and females, and 3-5 samples per age, sex and treatment were sequenced.

2022-07-13 | GSE207865 | GEO

Gene expression data from control and REPTOR KO larvae after 6h rapamycin treatment

Project description:The first aim was to identify genes whose transcription is induced by rapamycin feeding in Drosophila larvae. Secondly, the goal was to find out which contribution the transcription factor REPTOR (=CG13624) has to the observed changes in expression. We thus compared gene epxression between rapamycin fed and control fed larvae in wild type larvae and in REPTOR KO larvae.

2015-04-30 | GSE55220 | GEO

Gene expression data from control and REPTOR KO larvae after 6h rapamycin treatment

2015-04-30 | E-GEOD-55220 | biostudies-arrayexpress

Changes in the expression of miRs in the aorta after 3 and 10 months of a high fat diet compared with normal diet

Project description:We tried to identify miRs that are differentially expresssed during atherogenesis. Aortic miRs expression profile in female apoe-/- mice after 3 and 10 months of a high fat diet were compared with female apoe-/- mice on normal diet. 4 Female apoe-/- mice (6-8 weeks) were fed on high fat diet for 3 months. 3 female apoe-/- mice (6-8 weeks) were fed on high fat diet for 10 months. 4 female apoe-/- mice (6-8 weeks) on normal diet served as controls. Total RNA was isolated from whole aortic tissue. RNA samples with RIN>8 were used for array. The aortic miRs expression profile after 3 months of a high fat diet was compared with the control group. Biological replicates: 4 per group. One replicate per array.

2014-01-01 | E-GEOD-26557 | biostudies-arrayexpress

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