Gene expression changes caused by YAP overexpression and Nf2 deletion in the developing mouse brain

ABSTRACT: The transcriptional coactivator YAP is the key downstream effector of the Hippo pathway. YAP overexpression in the developing mouse brain results in excessive expansion of the neural progenitor pool and severe perturbation of brain development. Nf2/Merlin is a tumor suppressor whose mutations are found in many human cancers. Loss of Merlin during brain development causes overexpansion of the neural progenitor pool. We used microarrays to identify the gene expression changes caused by YAP overexpression and Nf2 deletion.

ORGANISM(S): Mus musculus

PROVIDER: GSE48078 | GEO | 2013/06/19

SECONDARY ACCESSION(S): PRJNA208861

REPOSITORIES: GEO