Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling

ABSTRACT: We performed gene expression profiling of oligooxopiperazines (OPs) targeting the hypoxia-inducible transcription factor complex. Treatment of cells with OPs inhibited hypoxia-inducible gene expression in A549 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE48134 | GEO | 2013/06/30

SECONDARY ACCESSION(S): PRJNA208988

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Designed Oligooxopiperazines as Modulators of Hypoxia-Inducible Factor Signaling

Project description:We performed gene expression profiling for designed oligooxopiperazines targeting the hypoxia-inducible transcription factor complex, which resulted in an effective inhibition of hypoxia-inducible genes with relatively minimal perturbation of non-targeted signaling pathways. Hypoxic A549 cells were treated with transcriptional inhibitors BB2-162, BB2-125, BB2-282 or vehicle and their expression profiles were compared to normoxic A549 cells treated with vehicle.

2013-06-30 | E-GEOD-48134 | biostudies-arrayexpress

Protein Domain Mimetics as In Vivo Modulators of Hypoxia-Inducible Factor Signaling

Project description:We performed gene expression profiling of hydrogen-bond surrogate that targets hypoxia-inducible transcription factior complex and results in inhibition of hypoxia-inducible genes with relatively minimal perturbation of non-targeted signaling pathways.

2013-06-18 | GSE48002 | GEO

Protein Domain Mimetics as In Vivo Modulators of Hypoxia-Inducible Factor Signaling

Project description:We performed gene expression profiling with oligonucleotide microarrays of hydrogen-bond surrogate targheting hypoxia-inducibletranscription factior complex, which resulted in an effective inhibition of hypoxia-inducible genes with relatively minimal perturbation of non-targeted signaling pathways. Hypoxic HeLa cells were treated with transcriptional inhibitors HBS 1, HBS 2 or vehicle and their expression profiles were compared to normoxic HeLa cells

2013-06-18 | E-GEOD-48002 | biostudies-arrayexpress

Regulation of hypoxia-inducible factor activity by CHD4

Project description:Regulation of hypoxia-inducible factor activity by CHD4

| PRJNA530760 | ENA

Regulation of hypoxia-inducible factor activity by ZMYND8

Project description:Regulation of hypoxia-inducible factor activity by ZMYND8

| PRJNA428761 | ENA

Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma with a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Project description:Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma with a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

2020-09-10 | GSE147595 | GEO

Hypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.

Project description:Hypoxia inducible factor 1 (HIF1) has been shown to cooperate with the androgen receptor (AR) in activation of oncogenic pathways in prostate cancer (PCa). Here we hypothesized that HIF1 also plays a role in PCa response to androgen deprivation therapy (ADT). Comparison of gene expression profiles of androgen exposed (AE) and androgen deprived (AD) CWR22 PCa xenografts identified 596 upregulated and 748 downregulated genes after ADT. Gene ontology (GO) analysis of the differentially expressed genes showed significant enrichment of the biological processes cell proliferation, cell cycle and metabolism and suggested suppression of these processes after ADT. A set of 80 hypoxia-inducible genes were identified in 22Rv1 and LNCaP cell lines treated with hypoxia and showed considerable overlap (53%) with the downregulated genes. Immunostaining of the hypoxia marker pimonidazole showed no difference between AE- and AD-tumors. Comparison of the differentially expressed genes with lists of 1115 direct AR- and 276 direct HIF1-target genes identified 138 AR- and 40 HIF1-targets that were regulated after ADT, including six shared AR- and HIF1-targets for which downregulation was confirmed with RT-PCR. Most HIF1-targets were downregulated and included in the significant biological processes and the set of hypoxia-inducible genes. The downregulation of HIF1-targets was consistent with decreased HIF1A immunostaining in AD- compared to AE-tumors (p=0.002). A decrease in HIF1A immunostaining after ADT was also demonstrated in a cohort of 35 PCa patients (p<0.001). These data suggest suppressed HIF1-signaling after ADT and a shared role of HIF1 and AR in the regressive phase of PCa after ADT. Prostate cancer xenografts were subjected to adrogen deprivation therapy and analysed with regard to changes in gene expressions. Cell culture experiments were performed to generate prostate cancer specific gene lists associated with hypoxia.

2013-10-02 | E-GEOD-42868 | biostudies-arrayexpress

Hypoxia-independent downregulation of hypoxia inducible factor 1 targets by androgen deprivation therapy in prostate cancer.

2013-10-02 | GSE42868 | GEO

Hypoxia Inducible Factor 1 Confers Androgen Independence in Prostate Cancer

Project description:Hypoxia Inducible Factor 1 Confers Androgen Independence in Prostate Cancer

| PRJNA472393 | ENA

Activation of g-globin expression by hypoxia-inducible factor 1a

Project description:Activation of g-globin expression by hypoxia-inducible factor 1a

| PRJNA764707 | ENA