Genomics

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Genome-wide Profiling of FOXA2 and POL2 binding in the mouse uterus [ChIP-Seq]


ABSTRACT: Forkhead box A2 (FOXA2) is a critical regulator of endometrial gland development in mice. In the adult mouse uterus, FOXA2 is expressed solely in the GE cells of the endometrium. Conditional deletion of Foxa2 after birth in the uterus, using the progesterone receptor Cre mouse (PgrCre), impeded gland development, thereby rendering the adult mouse infertile due to defects in blastocyst implantation stemming from a lack of endometrial glands and their secretions. As a first step to begin understanding the FOXA2 function in the endometrial glands of the uterus, genome-wide investigation of in vivo FOXA2 and RNA polymerase II (POL2) binding target regions in the neonatal and adult uterus was determined by chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq).

ORGANISM(S): Mus musculus

PROVIDER: GSE48238 | GEO | 2013/12/01

SECONDARY ACCESSION(S): PRJNA209329

REPOSITORIES: GEO

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