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Homo sapiens Ewing sarcoma cell line RD-ES: Negative control vs. HDGF knockdown

ABSTRACT: Comparing the gene expression profiling of HDGF-silenced RD-ES cells and control RD-ES cells to identify genes regulated by HDGF in RD-ES cells. Keywords: expression analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE48289 | GEO | 2013/06/27

SECONDARY ACCESSION(S): PRJNA209694

REPOSITORIES: GEO

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Homo sapiens Ewing sarcoma cell line RD-ES: Negative control vs. HDGF knockdown

Project description:Comparing the gene expression profiling of HDGF-silenced RD-ES cells and control RD-ES cells to identify genes regulated by HDGF in RD-ES cells. Keywords: expression analysis Control RD-ES cells and HDGF-silenced RD-ES cells were profiled on 22K Human Genome Array

2013-06-27 | E-GEOD-48289 | biostudies-arrayexpress

Ewing sarcoma compared to a normal body map

Project description:Primary pediatric Ewing sarcoma (ES), one uncharacterized sarcoma as well as primary and well established ES cell lines were compared to probes of different normal tissues 8 Ewing sarcoma patient samples (MuET-x), 3 primary ES cell lines (SB-KMS-y), 3 well established ES cell lines (A673, SK-N-MC, RD-ES) and 22 normal tissues (PBMC, spleen, thymus, stomach, ...., uterus, fetal brain, fetal liver) were analyzed.

2013-05-01 | E-GEOD-45544 | biostudies-arrayexpress

Homo sapiens

Project description:Homo sapiens Ewing sarcoma cell line RD-ES: Negative control vs. HDGF knockdown

| PRJNA209694 | ENA

Expression profiling of Ewing sarcoma cell lines exposed to 5nM Pladienolide B (PlaB) for 24 hours

Project description:Identification of genes and pathways altered by PlaB, a bacterial natural product that acts as a spliceosome modulator by targeting the SF3b subunit of the spliceosome SKNMC, TC32, TC71, and RD-ES Ewing sarcoma cell lines were treated with 0.1% (v/v) DMSO vehicle or 5nM PlaB for 24 hours. Three samples in each group were analyzed.

2016-01-15 | E-GEOD-67548 | biostudies-arrayexpress

Haemophilus influenzae Rd KW20 strain:Rd

Project description:Haemophilus influenzae Rd KW20 strain:Rd Genome sequencing

| PRJNA237703 | ENA

In Vitro Characterization of MHH-ES-1 Preclinical Radiation-Adapted Model for Ewing Sarcoma

Project description:Analysis of differentially expressed genes in wild type MHH-ES-1 Ewing Sarcoma cells when compared to MHH-ES-1 Ewing Sarcoma cells that received six 4 Gy fractions (cumulative dose of 24 Gy) of ionizing radiation (radiation-adapted cell line). The hypothesis tested being that repeated ionizing radiation exposure of modifies radiation therapy response in Ewing Sarcoma.

2017-05-10 | GSE98709 | GEO

Outer membrane vesicle and outer membrane of Haemophilus influenzae Rd KW20, Rd ∆yrbE and Rd ∆vacJ

Project description:Bacterial outer membrane vesicles (OMVs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of OMV formation is lacking. Here we show that the VacJ/Yrb ABC transport system, a proposed phospholipid (PL) transporter, is involved in OMV formation. Deletion or repression of VacJ/Yrb increases OMV production in two distantly related Gram-negative bacteria, Haemophilus influenzae and Vibrio cholerae. Within our studies we also analyzed the proteome of the OMV and outer membrane (OM) and found no massive alteration in Haemophilus influenzae Rd KW20, Rd ∆yrbE and Rd ∆vacJ. Lipidome analyses demonstrate that OMVs from VacJ/Yrb-defective mutants in H. influenzae are enriched in PLs and certain fatty acids. Furthermore, we demonstrate that OMV production and regulation of the VacJ/Yrb ABC transport system respond to iron starvation. Our results suggest a new general mechanism of OMV biogenesis based on PL accumulation in the outer leaflet of the outer membrane. This mechanism is highly conserved among Gram-negative bacteria, provides a means for regulation, can account for OMV formation under all growth conditions, and might have important pathophysiological roles in vivo.

2016-01-27 | PXD003249 | Pride

RD effect on PC-3 cells

Project description:RD induced DNA damage and suppressed DNA repair in PC-3 cells. Expression profiling of PC-3 cells treated with 10 umol/L RD for 24 hours.

2012-05-08 | GSE37812 | GEO

miRNA expression profiles from Ewing sarcoma samples, Ewing sarcoma cell lines and mesenchymal stem cells

Project description:For the identification of differentially expressed miRNA relevant for ES pathogenesis and clinical behaviour miRNA expression profiling of 377 miRNAs for 40 fresh-frozen ES samples, including primary cases and metastases and cases with different translocation types and 6 ES cell lines and compared these to those of MSCs from 6 healthy donors as the potential cells of origin were generated

2012-10-23 | E-MTAB-1337 | biostudies-arrayexpress

RD effect on PC-3 cells

Project description:RD induced DNA damage and suppressed DNA repair in PC-3 cells. Expression profiling of PC-3 cells treated with 10 umol/L RD for 24 hours. Total RNA was extracted from PC-3 cells exposed to RD for 24 h using an RNAiso plus kit (TaKaRa). Microarray analysis was performed on separate samples on the Affymetrix HG-U133 plus 2 chip.

2012-05-07 | E-GEOD-37812 | biostudies-arrayexpress

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