Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Time-dependent changes in gene expression after endotoxinic challenge followed by LR12-scrambled or LR12 treatment.

ABSTRACT: Gene expression assessment in blood from male Cynomolgus monkey after endotoxin challenge followed by intravenous infusion with peptide control (LR12-scrambled) or LR12. The samples were analyzed at different time-points: 0, 2, 4 and 8 hours

ORGANISM(S): Homo sapiens Macaca fascicularis

PROVIDER: GSE48311 | GEO | 2013/06/27

SECONDARY ACCESSION(S): PRJNA209645

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Time-dependent changes in gene expression after endotoxinic challenge followed by LR12-scrambled or LR12 treatment.

Project description:Gene expression assessment in blood from male Cynomolgus monkey after endotoxin challenge followed by intravenous infusion with peptide control (LR12-scrambled) or LR12. The samples were analyzed at different time-points: 0, 2, 4 and 8 hours 56 samples : 4 time points, 4 vehicle samples/time point, 4 peptide control samples/time point, 6 LR12 samples/time point

2013-06-27 | E-GEOD-48311 | biostudies-arrayexpress

Gene expression Profiling of Peripheral Blood Leukocytes after Endotoxin Challenge in Humans

Project description:Peripheral blood mononuclear cells were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge. Keywords: time course

2006-01-17 | GSE3026 | GEO

SCRaMbLEd synII

Project description:SCRaMbLEd synII

| PRJEB23542 | ENA

TMT-based quantitative proteomics of young and old cynomolgus monkey heart

Project description:TMT-based quantitative proteomics of young and old cynomolgus monkey heart.

2022-09-13 | PXD036689 | iProX

LC-MS/MS identification of BMAL1 interaction proteins

Project description:Advances in circadian research revealed an intricate relationship between aging and circadian rhythms. However, whether and how the circadian machinery contribute to stem cell aging, especially in primates, remains poorly understood. In this study, we investigated the role of BMAL1, the only non-redundant circadian clock component, during aging in mesenchymal progenitor cells (MPCs). We observed an accelerated aging phenotype in both BMAL1 deficient human and cynomolgus monkey MPCs. Notably, this phenotype is mainly attributed to a transcriptional-independent role of BMAL1 in stabilizing the heterochromatin and thus preventing LINE1 activation. In senescent MPCs from human and cynomolgus monkeys, dampened LINE1 binding capacity of BMAL1 and synergistically activated LINE1 transcripts were observed. Furthermore, similar de-stabilized heterochromatin and aberrant LINE1s transcription was observed in the skin and muscle tissues from BMAL1-deficient cynomolgus monkey. Altogether, these findings uncover a noncanonical role of BMAL1 in stabilizing heterochromatin to inactivate LINE1 that drives aging in primates.

2022-03-18 | PXD030570 | Pride

Genome-wide copy number variation profiling in Cynomolgus monkeys using customized NimbleGen CGH microarrays

Project description:Cynomolgus monkeys are well-established translational models for biomedical research and drug testing. Cynomolgus monkeys are outbred species and exhibit substantial levels of genetic variation which can affect the outcome and interpretation of biomedical studies. Copy number variations (CNVs) are a significant source of genetic diversity and a comprehensive understanding of the genomic impact of CNVs on phenotypic traits is limited. A custom 4.2 million probes comparative genomic hybridization (CGH) array (Design-ID: 120405_Cynomolgus5_CGH_UX1) has been designed on the basis of the Cynomolgus monkey genome (Ebeling et al. (2011) Genome Research; PMID: 21862625) to assess genome-wide copy number variation among Cynomolgus monkeys. Using Cynomolgus monkey specific NimbleGen CGH Microarrays we profiled the genomes of 21 Cynomolgus monkeys. Germline DNA from 21 Cynomolgus monkeys with different origin was tested against a Cynomolgus monkey reference. Cynomolus monkey samples were derived from breeding centers located in the Philippines (3 females and 3 males), in Vietnam (2 males and 2 females), in China for animals from Mainland Southeast Asia (3 females), or in Mauritius (4 females and 4 males). Furthermore genome-wide expression profiles were analyzed in 5 vitally important tissue samples (heart, kidney, liver, lung, spleen) from the same animals using a custom Cynomolgus monkey specific NimbleGen gene expression microarray (design ID: 120419_Cynomolgus_v5_TH_exp_HX12) to associate CNV genotypes with expression changes of proximal genes using a cis expression quantitative trait loci (cis-eQTL) mapping approach. Expression data have been deposited at the NCBI Gene Expression Omnibus (GEO) under accession numbers GSE76560. The array CGH results analyzed in this study are further described in Gschwind A.R. et al. (2016) "Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis". under submission

2016-02-24 | GSE76707 | GEO

The morphological and functional differences and similarities of immune cells between non-human primates and humans [monkey]

Project description:Comparison of the gene expression profiles of human and cynomolgus monkey PBMCs in response to PHA and LPS

2018-11-28 | GSE90722 | GEO

The morphological and functional differences and similarities of immune cells between non-human primates and humans [human]

Project description:Comparison of the gene expression profiles of human and cynomolgus monkey PBMCs in response to PHA and LPS

2018-11-28 | GSE90721 | GEO

Developmental trajectory of unconventional T cells of the cynomolgus macaque thymus

Project description:We profiled the differentiation pathways and heterogeneity of thymocytes in the young cynomolgus monkey thymus using single-cell RNA sequencing.

2024-05-19 | GSE267379 | GEO

A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys [RNA-seq]

Project description:Non-human primates (NHP) are attractive laboratory animal models that accurately reflect both developmental and pathological features of humans. Here we present a compendium of cell types from the cynomolgus monkey Macaca fascicularis (denoted as ‘Monkey Atlas’) using both single-cell chromatin accessibility (scATAC-seq) and RNA sequencing (scRNA-seq) data at the organism-wide level. The integrated cell map enables in-depth dissection and comparison of molecular dynamics, cell-type composition and cellular heterogeneity across multiple tissues and organs. Using single-cell transcriptomic data, we inferred pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes. Furthermore, we identified various cell-specific cis-regulatory elements and constructed organ-specific gene regulatory networks at the single-cell level. Finally, we performed a comparative analysis of single-cell landscapes among mouse, cynomolgus monkey and human, and we showed that cynomolgus monkey has significantly higher degree of cell-type similarity to human than mouse. Taken together, our study provides a valuable resource for NHP cell biology.

2022-06-27 | GSE196792 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data