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MicroRNA (miRNA) expression data from induced pluripotent stem cell (iPSC)-derived neurons exposed to soman/GD

ABSTRACT: Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized microRNA (miRNA) analysis to evaluate potential direct cellular effects of the nerve agent GD/soman (O-Pinacolyl methylphosphonofluoridate) on human-induced pluripotent stem cell (iPSC)-derived neurons

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE48669 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA211007

REPOSITORIES: GEO

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microRNA (miRNA) expression data from induced pluripotent stem cell derived (iPSC) derived cardiomyocytes exposed to soman/GD

Project description:Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized microRNA (miRNA) analysis to evaluate potential direct cellular effects of the nerve agent GD/soman (O-Pinacolyl methylphosphonofluoridate) on human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes

2013-12-31 | GSE48469 | GEO

microRNA (miRNA) expression data from induced pluripotent stem cell (iPSC)-derived neurons exposed to soman/GD

2013-12-31 | E-GEOD-48669 | biostudies-arrayexpress

microRNA (miRNA) expression data from induced pluripotent stem cell derived (iPSC) derived cardiomyocytes exposed to soman/GD

2013-12-31 | E-GEOD-48469 | biostudies-arrayexpress

microRNA (miRNA) expression data from induced pluripotent stem cell derived (iPSC) derived cardiomyocytes exposed to VX

2013-12-31 | GSE48470 | GEO

microRNA (miRNA) expression data from induced pluripotent stem cell (iPSC)-derived neurons exposed to VX

Project description:Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized microRNA (miRNA) analysis to evaluate potential direct cellular effects of the nerve agent VX (o-ethyl-s-[2 (diisopropylamino) ethyl] methylphosphonothiolate) on human-induced pluripotent stem cell (iPSC)-derived neurons

2013-12-31 | GSE48670 | GEO

microRNA (miRNA) expression data from induced pluripotent stem cell derived (iPSC) derived cardiomyocytes exposed to VX

Project description:Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized microRNA (miRNA) analysis to evaluate potential direct cellular effects of the nerve agent VX (o-ethyl-s-[2 (diisopropylamino) ethyl]) on human (iPSC)-derived neurons and iPSC-derived cardiomyocytes. iPSC-derived cardiomyocytes were treated with VX at concentrations of 0µM (saline control), 0.1µM or 100µM for either 1 hour or 6 hours. Total RNA was then isolated and processed for miRNA microarray analysis using Affymetrix miRNA 2.0 GeneChips

2013-12-31 | E-GEOD-48470 | biostudies-arrayexpress

microRNA (miRNA) expression data from induced pluripotent stem cell (iPSC)-derived neurons exposed to VX

Project description:Chemical warfare nerve agents (CWNA) are potent cholinesterase inhibitors that may also have non-cholinesterase effects. Several in vivo studies have shown that exposure to CWNA compounds induces damage in the brain and heart. Underlying mechanisms of this damage are a critical area of research for the development of medical countermeasures. This study utilized microRNA (miRNA) analysis to evaluate potential direct cellular effects of the nerve agent VX (o-ethyl-s-[2 (diisopropylamino) ethyl] methylphosphonothiolate) on human-induced pluripotent stem cell (iPSC)-derived neurons iPSC-derived neurons were treated with VX at concentrations of 0µM (saline control), 0.1µM or 100µM for either 1 hour or 6 hours. Total RNA was then isolated and processed for miRNA microarray analysis using Affymetrix miRNA 2.0 GeneChips

2013-12-31 | E-GEOD-48670 | biostudies-arrayexpress

Transcriptomics study on mouse treated with different doses of soman for 1, 3, 7 and 14 day.

Project description:Soman is a highly toxic lipophilic chemical warfare nerve agent that can cause serious brain damage, leading to death due to intense seizures and neuronal injury. The potential risks of low-dose soman exposure have been a cause for concern for a long time. However, the understanding of the complex biological changes that lead to persistent neurocognitive dysfunction induced by soman is still limited. In this work, we studied the response of mice to soman by measuring transcriptomics experiments. Mice were administered soman subcutaneously at 1/10, 1/5 or 1/2 of the 50% lethal dose and were sampled at 1, 3, 7 and 14 days. Each group has 3 biological replicates.

2023-07-20 | GSE237507 | GEO

microRNA (miRNA) expression data from normal human epidermal keratinocytes exposed to sulfur mustard and nitrogen mustard in the presence and absence of hydrocortisone treatment

Project description:The bifunctional alkylating agent sulfur mustard (SM; bis-(2-dichloroethyl) sulfide) is a potent vesicating chemical that has previously been used as a chemical warfare agent. studies have shown that exposure to CWNA compounds induces damage in the brain and heart.

2016-08-30 | GSE54639 | GEO

Evaluating Mice lacking Serum Carboxylesterase as a Behavioral Model for Nerve Agent Intoxication

Project description:Mice and other rodents typically used for nerve agent research have high concentrations of carboxylesterase in the blood that can act as natural scavengers for nerve agents. To develop an improved rodent system for the study of chemical warfare nerve agents, a serum carboxylesterase knock out mouse model was made (Es-1 knock out). This study utilized mRNA analysis to evaluate the effects of knocking out the serum carboxylesterase in a mouse model.

2018-05-04 | GSE114024 | GEO

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