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Gene expression profile of Tet1 knockout cortex and hippocampus

ABSTRACT: Global gene expression profile of Tet1 knocout cortex or hippocampus is compared to wild-type cortex or hippocampus. All mice used are naïve and of mixed 129 C57BL6 backgound.

ORGANISM(S): Mus musculus

PROVIDER: GSE48789 | GEO | 2013/09/01

SECONDARY ACCESSION(S): PRJNA211730

REPOSITORIES: GEO

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Gene expression profile of Tet1 knockout cortex and hippocampus

Project description:Global gene expression profile of Tet1 knocout cortex or hippocampus is compared to wild-type cortex or hippocampus. All mice used are naM-CM-/ve and of mixed 129 C57BL6 backgound. Tet1 KO in brain cortex and hippocampus

2013-09-01 | E-GEOD-48789 | biostudies-arrayexpress

Gene expression profile of Tet1 knockout mouse embryonic stem cells (mESCs)

Project description:Global gene expression profile of Tet1 knockout ES cells is compared to wild-type ES cells. All ES lines used are V6.5 (mix 129 C57BL6 backgound).

2011-08-01 | GSE30748 | GEO

Gene expression profile of Tet1 knockout mouse embryonic stem cells (mESCs)

Project description:Global gene expression profile of Tet1 knockout ES cells is compared to wild-type ES cells. All ES lines used are V6.5 (mix 129 C57BL6 backgound). 2 Tet1 KO mice compared to 1 Tet1 wild type mouse.

2011-07-31 | E-GEOD-30748 | biostudies-arrayexpress

RNA-seq of Egr1-/- and Tet1-/- mouse frontal cortex

Project description:We performed transcriptome profiling for frontal cortex tissues derived from 6~8 week old Egr1-/- and Tet1-/- mice.

2019-07-25 | GSE108750 | GEO

Sex differences in neonatal mouse cortex/hippocampus gene expression

Project description:Analysis of mouse genes showing a sex difference in gene expression in the cortex and hippocampus on the day of birth 17 samples, all collected on the afternoon of birth (1pm-3pm local), including 9 male and 8 female samples. All samples include both cortex and hippocampus dissected out from other brain.

2014-01-23 | E-GEOD-54283 | biostudies-arrayexpress

RRBS (Reduced Representation Bisulfite Sequencing) of Egr1-/- and Tet1-/- mouse frontal cortex

Project description:We performed methylome profiling for mouse frontal cortex tissues derived from 6~8 week old Egr1-/- and Tet1-/- mice.

2019-07-25 | GSE108762 | GEO

miRNA expression profiles of frontal cortex and hippocampus from adult C57BL/6J mice

Project description:We used Affymetrix miRNA arrays to analyze the expression of miRNAs in the frontal cortex and hippocampus of 8-week-old C57BL/6J wt mice. We compared these microarray-based expression profiles to ones obtained by miRNA sequencing from the same brain regions of the same mouse strain. miRNA expression profiling of frontal cortex and hippocampus from C57BL/6J mice (N=3) was performed with Affymetrix miRNA array

2011-06-22 | E-GEOD-27891 | biostudies-arrayexpress

Transcriptome analysis of whole hippocampus from wild-type and TET1-deficient mice after electroconvulsive shock

Project description:We examined the effect of TET1 deletion on activity-dependent gene regulation by comparing RNA-seq expression profiles from the hippocampus of ECS-treated Tet1Δe4-/- and Tet1+/+ mice. We discovered that 34 genes were significantly upregulated and 184 genes were downregulated, suggesting a primary role for TET1 in activating gene expression. In order to test the hypothesis that TET1 is responsible for regulating activity-dependent genes, we cataloged a dataset of activity-dependent genes based on a literature review. While there was not significant enrichment for activity-dependent genes disrupted in Tet1-deficient mice, dysregulation of several activity-dependent genes were identified including the master memory gene regulator, Npas4. Gene Ontology analyses of the dysregulated genes detected a significant enrichment for genes involved in the extracellular region/matrix/space. Interestingly, RNA-seq revealed downregulation of Oxtr, the receptor which binds oxytocin.

2019-02-15 | GSE99674 | GEO

Sex differences in neonatal mouse cortex/hippocampus gene expression

Project description:Analysis of mouse genes showing a sex difference in gene expression in the cortex and hippocampus on the day of birth

2014-01-23 | GSE54283 | GEO

Expression data from hippocampus and cortex of 6- and 12-week curcumin-treated 15-month-old rats

Project description:Curcumin has been demonstrated to have many neuroprotective properties, including improvement of cognition in humans and neurogenesis in animals, yet the mechanism of such effects remains unclear. Here, we assessed behavioural performance and hippocampal cell proliferation in aged rats after 6- and 12-week curcumin-fortified diets. Curcumin enhanced non-spatial and spatial memory, as well as dentate gyrate cell proliferation as compared to control diet rats. We also investigated underlying mechanistic pathways that might link curcumin treatment to increased cognition and neurogenesis via microarray analysis of cortical and hippocampal mRNA transcription. We used microarrays to investigate the effects of short-term (6-week) and long-term (12-week) curcumin-supplemented diet on gene expression of hippocampus and cortex in aged rats. The hippocampus and cortex of every three rats from one group were pooled together, respectively and used for RNA extraction and hybridization on Affymetrix microarrays. To ensure the reliability of the data, we conducted hybridization experiments in duplicate microarrays from each RNA sample. The tissues examined by microarray are as follows: the hippocampus and cortex of 6-week curcumin-treated 15-month-old rats, the hippocampus and cortex of 6-week no curcumin-treated 15-month-old rats (control rats), the hippocampus and cortex of 12-week curcumin-treated 15-month-old rats, the hippocampus and cortex of 12-week no curcumin-treated 15-month-old rats (control rats).

2011-10-21 | E-GEOD-33137 | biostudies-arrayexpress

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