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Differentially expressed genes after inhibition of methylation

ABSTRACT: Expression microarray of livers from 4 dpf control zebrafish larvae, larvae treated with azacytidine, and ahcy mutant larvae Comparison of expression from livers obtained from ahcy+/+ treated with vehicle, ahcy+/+ treated with azacytidine, and ahcy-/- treated with vehicle.

ORGANISM(S): Danio rerio

PROVIDER: GSE48804 | GEO | 2013/07/11

SECONDARY ACCESSION(S): PRJNA211820

REPOSITORIES: GEO

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Differentially expressed genes after inhibition of methylation

Project description:Expression microarray of livers from 4 dpf control zebrafish larvae, larvae treated with azacytidine, and ahcy mutant larvae Comparison of expression from livers obtained from ahcy+/+ treated with vehicle, ahcy+/+ treated with azacytidine, and ahcy-/- treated with vehicle. We treated larvae starting at 2 dpf with 1 mM azacytidine or vehicle control. Livers were removed at 4 dpf, RNA isolated, and double amplified.

2013-07-11 | E-GEOD-48804 | biostudies-arrayexpress

Differentially expressed genes associated with hepatic steatosis in zebrafish

Project description:Expression microarray of livers from adult zebrafish: control, overfed, and ahcy+/- Comparison of expression from livers obtained from ahcy+/+, overfed ahcy+/+, ahcy+/- control and ahcy+/- overfed. Adult zebrafish, ahcy+/+ and +/-, were given a regular diet or were overfed for a month. Livers were removed, RNA isolated, and expression microarray was performed.

2013-10-01 | E-GEOD-48806 | biostudies-arrayexpress

Differentially expressed genes associated with hepatic steatosis in zebrafish

2013-10-01 | GSE48806 | GEO

Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model [miRA-seq]

Project description:Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control.

2020-03-03 | GSE146200 | GEO

Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model [RNA-seq]

Project description:Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control.

2020-03-03 | GSE146199 | GEO

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish

Project description:ATF6 is a key regulator of the unfolded protein response. Through use of zebrafish and cultured cells we demonstrate that ATF6 drives fatty liver disease by interaction with fatty acid synthase (FASN). Total small RNA from livers of 5 dpf larval zebrafish were collected: 2 batches of Tg(fabp10:nls-mCherry) control larvae, 2 batches of ethanol-treated Tg(fabp10:nls-mCherry) larvae, and 1 batch of Tg(fabp10:nAtf6-cherry; cmlc2:GFP). Each batch was purified for preparation of high-throughput sequencing libraries.

2014-05-01 | E-GEOD-56498 | biostudies-arrayexpress

Metabolomics analysis of zebrafish response to CID661578 treatment

Project description:zebrafish larvae were treated with DMSO or CID661578 for 24 hours prior to global metabolomics analysis (n=6). Metabolites were extracted from pools of 10 zebrafish larvae at 5 dpf using a 80% methanol-based extraction method. Samples were dried in speed vac and stored in -80C freezer until ready for LC-MS analysis.

2022-03-30 | ST002119 | MetabolomicsWorkbench

Transcriptome profiles of liver from 7dpf zebrafish larvae from control, sec31anju221 and double mutation of sec31anju221 and UPR effectors by Next Generation Sequencing

Project description:We found that zebrafish larvae bearing a homozygous hypomorphic mutation in the sec31a gene (sec31anju221) exhibited hepatic steatosis accompanied with activation of unfolded protein response (UPR). As systematic efforts to investigate how different branches of UPR impact on the hepatic metabolic maladaptation, critical effectors of the UPR (xbp1, atf4a/4b, atf6, srebf1 and srebf2) were separately knock-outed on sec31anju221 background. In order to access the changes on transcriptome landscape, livers were dissected from the 7 dpf zebrafish larvae and low input RNA-seq was applied.

2024-01-01 | GSE248098 | GEO

Effect of swim-training on caudal fin development in zebrafish larvae

Project description:Genome-wide microarray analysis of the effects of swim-training on caudal fin development in zebrafish larvae. Zebrafish were subjected to swim-training from 5 days post fertilization (dpf) until 10 dpf. Subsequently, we performed a genome-wide microarray analysis on the caudal fins of control and trained fish at 10 dpf. The goal of the project was to investigate the effects of swim-training on the gene expression level during caudal fin development in zebrafish larvae.

2014-07-17 | GSE44395 | GEO

Proteomics analysis of zebrafish spinal cord regeneration

Project description:Label-free mass spectrometry-based quantitative proteomics was applied to a larval zebrafish spinal cord injury model, which allows axon regeneration and functional recovery within two days (days post lesion; dpl) after a spinal cord transection in 3 day-old larvae (dpf). Proteomic profiling of the lesion site was performed at 1 dpl and 2 dpl as well as corresponding age-matched unlesioned control tissue (4 dpf as control for 1 dpl; 5 dpf as control for 2 dpl).

2023-09-06 | PXD037590 | Pride

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