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EZH2 Overexpression in Breast Cancer is due to MicroRNA-Dependent Suppression of ZBTB4

ABSTRACT: In order to Sp1 and EZH2-specific gene expression pattern in breast cancer, small interfering RNA for Sp1 and EZH2 was transfected in MDA-MB-231 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE48979 | GEO | 2015/03/02

SECONDARY ACCESSION(S): PRJNA212513

REPOSITORIES: GEO

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EZH2 Overexpression in Breast Cancer is due to MicroRNA-Dependent Suppression of ZBTB4

Project description:In order to Sp1 and EZH2-specific gene expression pattern in breast cancer, small interfering RNA for Sp1 and EZH2 was transfected in MDA-MB-231 cells. Four groups of samples are included: 1. si control (siCT_1, siCT_2, siCT_3). 2. siSp1 (siSp1_1, sisSp1_2, siSp1_3). 3. si control (siCT_A, siCT_B, siCT_C). 4. siEZH2 (siZEH2_1, siZEH2_2,siEZJ2_3). Gene expression profiles of Sp1 and EZH2 depleted cells were compared to that of siRNA controls. Experiments were performed in MDA-MB-231 cells.

2015-03-02 | E-GEOD-48979 | biostudies-arrayexpress

Genome wide map of EZH2 and SOX2 binding in mammospheres reveals common set of bound regions.

Project description:We generated genome wide map of EZH2 and SOX2 protein binding in MDA-MB-231 mammospheres and we discovered enrichment of both protein on the genes regulated by SCIRT

2021-02-23 | GSE136187 | GEO

Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2

Project description:The histone methyl transferase EZH2 and SMYD2 are master epigenetic regulators involved in histone methylation and gene transcription repression. Here, we report that SMYD2 and EZH2 may act as a complex in transcriptional regulation and are involved in the progression of breast cancer. ChIP-on-chip assays were performed to find unique promoters co-targeted by EZH2 and SMYD2 in MDA-MB-231 cells.

2019-11-03 | GSE126055 | GEO

Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2

Project description:Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2

| PRJNA520883 | ENA

Gene expression data of cancer cell lines treated with inhibitors of G9a and EZH2

Project description:Epigenetic modifications modulate gene expression and, when deregulated, contribute to the development and progression of cancer. G9a (EHMT2) and EZH2 are two histone methyltransferases commonly upregulated in several cancer types, leading to the silencing of tumor suppressor genes. We performed high throughput sequencing of a breast cancer cell line (MDA-MB-231), an ovarian cancer cell line (CAOV3) and a melanoma cell line (D14) treated with a G9a inhibitor (UNC0642), EZH2 inhibitor (GSK126) and their combination.

2022-02-20 | GSE168763 | GEO

HOTAIR transfected Breast Cancer Cells

Project description:MDA-MB-231 Breast Cancer Cells were infected by retroviral expression with either VECTOR or HOTAIR. To test the role of polycomb in HOTAIR mediated gene expression, MDA-MB-231 HOTAIR cells were infected with short hairpin retroviral vectors targeting SUZ12 or EZH2. A genetic modification design type is where an organism(s) has had genetic material removed, rearranged, mutagenized or added, such as knock out. genetic_modification_design

2010-04-15 | E-GEOD-20435 | biostudies-arrayexpress

Genome-wide maps of chromatin state in MDA-MB-231 cells [ChIP-seq]

Project description:We report a series of ChIP-Seq results in MDA-MB-231 cells. Briefly, we performed ChIP-Seq experiments with antibodies specific for PHF20L1, MTA1, EZH2, H3K27me2, H3K27me3 and H3K27ac in normal or knockdown of PHF20L1 MDA-MB-231 cells . We found that knockdown of PHF20L1 reduced the enrichment of MTA1, EZH2, H3K27me2, and H3K27me3 on the PHF20L1 target gene, and the enrichment of H3K27ac increased. This study gave us a new understanding of the role of PHF20L1 in chromatin status and gene transcription.

2020-03-12 | GSE128231 | GEO

HOTAIR transfected Breast Cancer Cells

2010-04-15 | GSE20435 | GEO

Effect of ARL11 overexpression on gene expression of MDA-MB-231 cells during olaparib treatment

Project description:To investigate the function ARL11 in the regulation of PARPi resistance, we established MDA-MB-231 cells overexpressing ARL11. We then performed gene expression profiling analysis using data obtained from RNA-seq of ARL11 overexpression or vector control MDA-MB-231 cells treated with or without Olaparib.

2024-05-25 | GSE233429 | GEO

NBAT1 overexpression effect on breast cancer cell line MDA-MB-231

Project description:Analysis of MDA-MB-231 breast cancer cells overexpressing lncRNA neuroblastoma associated transcript 1 (NBAT1). Results provide insight into the function of NBAT1 in breast cancer. NBAT1 overexpressed in breast cancer cells MDA-MB-231 compared to control (empty vector alone). Three replicates of each treatment were analyzed.

2015-04-21 | E-GEOD-68034 | biostudies-arrayexpress

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