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Expression data from mesenchymal stem cells of ossifying fibroma

ABSTRACT: Ossifying fibroma (OF) is a common benign fibro-osseous neoplasm of orofacial bones, showing progressive enlargement of the affected jaw with deficiency in bone formation. Our aim is to discover the molecular difference between mesenchymal stem cells from OF and normal jaw bone to provide basis for development of clinical therapy. Global gene expression comparison and gene ontology analysis found that several singaling pathways are involved in the process, including TGFb signaling and Notch signaling. Inhibition of TGFb signaling in mesenchymal stem cells of OF can increase the osteogenesis and decrease proliferation, shedding light on developing strategies for therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49165 | GEO | 2013/07/24

SECONDARY ACCESSION(S): PRJNA213187

REPOSITORIES: GEO

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Expression data from mesenchymal stem cells of ossifying fibroma

Project description:Ossifying fibroma (OF) is a common benign fibro-osseous neoplasm of orofacial bones, showing progressive enlargement of the affected jaw with deficiency in bone formation. Our aim is to discover the molecular difference between mesenchymal stem cells from OF and normal jaw bone to provide basis for development of clinical therapy. Global gene expression comparison and gene ontology analysis found that several singaling pathways are involved in the process, including TGFb signaling and Notch signaling. Inhibition of TGFb signaling in mesenchymal stem cells of OF can increase the osteogenesis and decrease proliferation, shedding light on developing strategies for therapy. RNA from mesenchymal stem cells of OF is compared to that of normal jaw bone.

2013-07-24 | E-GEOD-49165 | biostudies-arrayexpress

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Homo sapiens

Project description:Expression data from mesenchymal stem cells of ossifying fibroma

| PRJNA213187 | ENA

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