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Genome wide differential H3K4me2 and H3K27me3 profile of spermatozoa from high and sub-fertility buffalo bulls

ABSTRACT: Sperm carries information to the presumptive embryo upon fertilization in terms of epigenetic codes and transcripts along with the haploid genome. The epigenetic code includes DNA methylation and Histone modifications. During spermatogenesis the chromatin of sperm undergoes wide level of modifications and histone proteins are replaced by Protamine proteins. But some modified Histone forms still remain and they carry epigenetic codes essential for fertility and embryo development. Through this work we are trying to see the difference between H3K4me2 and H3K27me3 kind of histone modifications in spermatozoa of high and low fertility buffalo bulls.

ORGANISM(S): Bubalus bubalis Bos taurus

PROVIDER: GSE49316 | GEO | 2014/12/24

SECONDARY ACCESSION(S): PRJNA213725

REPOSITORIES: GEO

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Genome wide profiling of buffalo (Bubalus bubalis) sperm DNA methylation in relation to bull fertility

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