Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chronic academic stress increases a group of microRNAs in peripheral blood

ABSTRACT: In this study, we examined alterations in microRNA (miRNA) profiles in peripheral blood from male medical students two months and two days before the National Examination for Medical Practitioners. Blood obtained one month after the examination were used as baseline controls. Several miRNAs were significantly elevated during the pre-examination period in association with significant down-regulation of their target mRNAs two days before the examination. Thus, a distinct group of miRNAs in periheral blood may participate in the integrated response to chronic academic stress in healthy young men

ORGANISM(S): Homo sapiens

PROVIDER: GSE49677 | GEO | 2013/08/09

SECONDARY ACCESSION(S): PRJNA214701

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Chronic academic stress increases a group of microRNAs in peripheral blood

Project description:In this study, we examined alterations in microRNA (miRNA) profiles in peripheral blood from male medical students two months and two days before the National Examination for Medical Practitioners. Blood obtained one month after the examination were used as baseline controls. Several miRNAs were significantly elevated during the pre-examination period in association with significant down-regulation of their target mRNAs two days before the examination. Thus, a distinct group of miRNAs in periheral blood may participate in the integrated response to chronic academic stress in healthy young men Total RNA was prepared from venous blood which was taken from young male medical students. 12 samples from 4 subjects at three time points: two months before, two days before, and one month fater the examination were measured on array platform.

2013-08-09 | E-GEOD-49677 | biostudies-arrayexpress

laughter regulates postprandial blood glucose levels and gene expression

Project description:Sample tissue: peripheral blood Disease: diabetes Samples for gene expression analysis were obtained before the meal and 1.5 hours after the event. Event: listening to a Japanese comic story or a monotonous academic lecture without humor. Keywords: equivalent probe

2004-10-21 | GSE1322 | GEO

Transcription profiling of human peripheral blood cells reveals laughter regulates postprandial blood glucose levels and gene expression

Project description:Sample tissue: peripheral blood; Disease: diabetes; Samples for gene expression analysis were obtained before the meal and 1.5 hours after the event. Event: listening to a Japanese comic story or a monotonous academic lecture without humor.

2008-06-11 | E-GEOD-1322 | biostudies-arrayexpress

AMC colon cancer AJCCII

Project description:Profiling project of CRC patient material collected in the Academic Medical Center (AMC) in Amsterdam, The Netherlands. We focused on a set of 90 AJCC stage II patients that underwent intentionally curative surgery in the years 1997-2006 (AMC-AJCCII-90). Extensive medical records are kept from these patients and long-term clinical follow-up is available for the large majority. Both paraffin-embedded as well as fresh frozen tissue is available from all these patients for analysis.

2011-11-05 | GSE33113 | GEO

Effect of 6 weeks of high fat diet on gene expression in human subcutaneous adipose tissue of twins

Project description:Food composition of diets strongly determines the risk of experiencing inflammation related metabolic or cardiovascular disease. We aimed to determine the extent of inheritance of inflammatory responses to isocaloric changes in food composition as a prerequisite of personalized dietary recommendations in human twins. 34 monozygotic and 12 dizygotic healthy pairs of twins recruited from a twin register (HealthTwiSt, Berlin, Germany) or by public advertisements completed the study. All participants received a low fat diet (55% carbohydrate, 30% fat, 15% protein) for 6 weeks (CID1=LF thereafter) followed by 6 weeks of a high fat diet (40% carbohydrate, 45% fat, 15% protein) (CID2=HF1 after 1 week, and CID3=HF6 after 6 weeks of high fat diet). Both diets were isocloric. A physical examination, anthropometry (DEXA scan), and medical history were obtained and 12h fasted blood was collected at 8:00 a.m. on study days. Resting energy expenditure (indirect calorimetry) and physical activity level (PAL) was assessed by questionnaire and dietary food records for five days were completed before and during the study. Fasting blood levels of cytokines, chemokines and adipokines were determined by ELISA. The participants were instructed, trained and accompanied by an experienced nutritionist. Individual energy requirements were calculated based on participants REE and PAL. Participants received a list of 94 foods items and individual daily meal plans on how to exchange and combine these foods and energy intake was adjusted according to body weight if needed. Seven days before the LF, HF1 and HF6 examination days 70 percent of the food was provided to ensure standardized dietary patterns for all participants. A biopsy of periumbilical abdominal subcutaneous adipose tissue was performed on each CID for gene expression analysis.

2014-10-10 | E-GEOD-62199 | biostudies-arrayexpress

AMC colon cancer AJCCII

2011-11-05 | E-GEOD-33113 | biostudies-arrayexpress

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype [adenomas]

Project description:Colorectal cancer can be divided into four consensus molecular subtypes, which might associate with distinct precursor lesions. The aim of this study was to determine the subtype affiliation of two types of colorectal adenomas: tubular adenomas (TAs) and sessile serrated adenomas (SSAs) and to determine the activity of TGFβ signaling and the role of this cytokine in subtype affiliation. Adenoma samples were collected in the Academic Medical Center (AMC), Amsterdam, The Netherlands. Tubular adenomas (TAs) were obtained from familial adenomatous polyposis (FAP) patients and sessile serrated adenomas (SSAs) were collected from serrated polyposis syndrome (SPS) patients.

2016-06-01 | GSE79460 | GEO

AMC tubular and serrated adenomas

Project description:Profiling project of a panel of tubular adenoma and serrated adenoma patient material collected in the Academic Medical Center (AMC) in Amsterdam, The Netherlands. The aim of the study was to compare the expression profiles of different types of colon cancer precursor lesions (tubular versus serrated adenomas) and determine their correspondence with a set of colon cancer patient-derived profiles that have distinct clinical outcomes.

2013-04-14 | GSE45270 | GEO

Human psychological stress plasma

Project description:Blood plasma was collected from 9 naval aviation students 24 hours prior to and no more than 20 minutes after Modular Egress Training (psychological stressor).

2009-12-01 | PRD000158 | Pride

MicroRNA expression in peripheral blood predicts poor and prolonged response to sunitinib.

Project description:Peripheral blood samples were taken before initiation of therapy and 2 weeks later from patients with advanced renal cell carcinoma treated with sunitinib in first line. MicroRNA expression in peripheral blood was assessed using microarrays and several models predicting poor response and prolonged response to sunitinib were constructed and evaluated. Peripheral blood samples obtained before initiation of therapy with sunitinib and 14 days later were used to assess expression values of miRNAs.

2013-02-11 | E-GEOD-32099 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data