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MicroRNA expression profile in HEK293T cells infected with Chikungunya virus

ABSTRACT: HEK293T grown in 6 well plates were infected with CHIKV and total RNA was isolated from cells at 0, 12 and 24 hrs post infection. CHIKV microRNA expression signature was generated.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE49884 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA215241

REPOSITORIES: GEO

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Gene expression profile in HEK293T cells infected with Chikungunya virus

2014-01-20 | GSE49985 | GEO

microRNA expression profile in HEK293T cells infected with Chikungunya virus

Project description:HEK293T grown in 6 well plates were infected with CHIKV and total RNA was isolated from cells at 0, 12 and 24 hrs post infection. CHIKV microRNA expression signature was generated. Cells grown on 6-well plates. Three biological replicates of uninfected and two biological replicates of infected samples

2014-01-01 | E-GEOD-49884 | biostudies-arrayexpress

Gene expression profile in HEK293T cells infected with Chikungunya virus

Project description:HEK293T grown in 6 well plates were infected with CHIKV and total RNA was isolated from cells at 0, 12 and 24 hrs post infection. CHIKV gene expression signature was generated. Cells grown on 6-well plates. Three biological replicates of uninfected and two biological replicates of infected samples

2014-01-20 | E-GEOD-49985 | biostudies-arrayexpress

Chikungunya virus

Project description:ARUBA CHIKV

| PRJDB8750 | ENA

Transcriptome profile of the host antiviral response to Chikungunya virus infection in human monocyte-derived macrophages (MDMs)

Project description:Chikungunya virus (CHIKV) infection is characterized by alterations in gene expression profile on host cells that consequently lead to an immune response. Here, we used RNA sequencing to analyze the mRNA expression profile in human monocyte-derived macrophages (MDMs) infected with a Colombian clinical isolate of CHIKV at 6 and 24 hpi. analyze the mRNA expression profile in the human monocyte-derived macrophages infected at 6 and 24 hrs with a Colombian clinical isolate of Chikungunya virus.

2022-01-19 | GSE193977 | GEO

Chikungunya Virus Time Course Infection of Human Macrophages

Project description:Human monocyte-derived macrophage cells were infected with Chikungunya virus (CHIKV) to identify and quantify intracellular transcriptional changes that contribute to the host response to infection with CHIKV. RNA was collected from these cells at 8 and 24 hours post-infection (hpi) and were compared to mock-infected cells. The RNAseq data was then analyzed to determine the genes, functions, and signaling pathways that were significantly affected in an effort to predict existing drugs that could be repurposed as potential therapeutics for CHIKV.

2022-03-02 | GSE182287 | GEO

Temporal quantitative proteomics of Chikungunya virus infected cells

Project description:To better understand the complex CHIKV-host interplay we used stable isotope labeling with amino acids in cell culture (SILAC) and LC-MS/MS to define the temporal dynamics of the cellular response to infection. Using samples harvested at 8, 10 and 12 hours post infection, over 4700 proteins were identified and per time point 2750-3150 proteins could be quantified in both biological replicates.

2015-03-16 | PXD001330 | Pride

Chikungunya virus infection disrupts lymph node lymphatic endothelial cell composition and function via MARCO

Project description:Infection with chikungunya virus (CHIKV) causes disruption of draining lymph node (dLN) organization, including paracortical relocalization of B cells, loss of the B cell-T cell border, and lymphocyte depletion that is associated with infiltration of the LN with inflammatory myeloid cells. Here, we find that during the first 24 h of infection, CHIKV RNA accumulates in MARCO-expressing lymphatic endothelial cells (LECs) in both the floor and medullary LN sinuses. The accumulation of viral RNA in the LN was associated with a switch to an antiviral and inflammatory gene expression program across LN stromal cells, and this inflammatory response, including recruitment of myeloid cells to the LN, was accelerated by CHIKV-MARCO interactions. As CHIKV infection progressed, both floor and medullary LECs diminished in number, suggesting further functional impairment of the LN by infection. Consistent with this idea, antigen acquisition by LECs, a key function of LN LECs during infection and immunization, was reduced during pathogenic CHIKV infection.

2024-01-31 | GSE243638 | GEO

Quantitative proteomic analysis of chikungunya virus-infected Aedes aegypti reveals proteome modulations indicative of persistent infection

Project description:The mosquito-borne chikungunya virus (CHIKV) poses a threat to human health in tropical countries throughout the world. The molecular interactions of CHIKV with its mosquito vector, Aedes aegypti are not fully understood. Following oral acquisition of CHIKV via salinemeals, we analyzed changes in the proteome of Ae. aegypti in 12 h intervals by label-free timsTOF Pro mass spectrometry. For each of the seven time points, between 2647 and 3167 proteins were identified among CHIKV infected and non-infected mosquito samples and fewer than 6% of those identified proteins were affected by the virus.

2020-03-18 | MSV000085115 | MassIVE

Transcription profiling by array of Vero cells infected by different Chikungunya virus strains to identify common human host genes involved in pathogenesis of different Chikungunya viruses

Project description:In this study, we aim to identify common host genes involved in pathogenesis of different Chikungunya virus strains as an attempt to recognize probable antiviral targets. We have compared the host gene regulation after infection of monkey kidney cell line (Vero) with two different wild type CHIKV strains i.e. S 27 (human, ECSA), and DRDE-06 (human, ECSA). Vero cells were mock infected or infected with two Chikungunya virus strains (S 27 and DRDE-06) and harvested at 8hpi and 18hpi. The total RNA was extracted and microarray was done using Agilent protocol.

2021-10-28 | E-MTAB-6645 | biostudies-arrayexpress

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