Racial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c

ABSTRACT: Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n=70) and white (n=84) subjects. Numerous differentially expressed (DE) RNAs were associated with both race and PAR4 reactivity, including phosphatidylcholine transfer protein (PCTP), and platelets from blacks expressed higher levels of PC-TP protein.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49921 | GEO | 2013/11/15

SECONDARY ACCESSION(S): PRJNA215334

REPOSITORIES: GEO